Sökning: "C17.2"

Visar resultat 1 - 5 av 10 avhandlingar innehållade ordet C17.2.

1. 1. Estimation of acute toxicity by using the differentiated neuronal progenitor C17.2 cell model

   Författare :Jessica Lundqvist; Anna Forsby; Ann-Kristin Östlund Farrants; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Neurotoxicity; C17.2; cell membrane potential; Optimisation culture condition; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Sammanfattning : The authorities in Europe and United States request information regarding possible toxicity for substances that are produced in one tonne or more per year. Estimation of acute systemic toxicity is conducted in vivo using mice or rats. LÄS MER

3. 2. Neuroblastoma SH-SY5Y and neural progenitor C17.2 cell lines as models for neurotoxicological studies​

   Författare :Jessica Lundqvist; Anna Forsby; Åsa Fex Svenningsen; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; SH-SY5Y; C17.2; in vitro neurotoxicity; cell culture conditions; biomarkers; in vitro developmental neurotoxicity; whole genome microarray; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Sammanfattning : We are surrounded by chemicals, thus understanding how exposure to these chemicals affect us during our life is of great social importance. In order to predict human acute toxicity of chemicals, cosmetics or drugs, development of novel in vitro test strategies is required. LÄS MER

4. 3. Apoptotic cell death in neural stem cells exposed to toxic stimuli

   Författare :Christoffer Tamm; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Neural stem cells (NSCs) play an important role in the developing nervous system and adulthood, where mitotic regions of the brain such as the subventricular zone (SVZ) remain active. In spite of the immense interest in NSC research, little is known about the biochemical regulation by which NSCs undergo cell death in the course of normal physiology or in response to neurotoxic insults. LÄS MER

5. 4. Apoptotic cell death in neural stem cells exposed to toxic stimuli

   Författare :Christoffer Tamm; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Neural stem cells (NSCs) play an important role in the developing nervous system and in the adult brain, where mitotic regions such as the subventricular zone (SVZ) remain active. In spite of the intense ongoing research on NSCs, we still need to expand the knowledge on biochemical regulation by which NSCs undergo cell death in the course of normal physiology or in response to neurotoxic insults. LÄS MER

7. 5. Novel Endpoints To Unravel Developmental Neurotoxicity : From DNA methylation responses to methylmercury to the in vitro identification of endocrine disruptors

   Författare :Andrea Cediel-Ulloa; Joëlle Rüegg; Pamela J. Lein; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Developmental neurotoxicity; Methylmercury; DNA methylation; Endocrine disruptors; in vitro assay development; Biology with specialization in Environmental Toxicology; Biologi med inriktning mot miljötoxikologi;

   Sammanfattning : The developing brain is especially sensitive to environmental stressors due to its dependence on the precise spatiotemporal regulation of multiple signals, and the long time period required for its formation. Some chemicals can interfere with molecular and cellular processes driving brain development, including epigenetic processes such as DNA methylation. LÄS MER