Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet immunotoxicity.
Sammanfattning : The environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces thymus atrophy and immunosuppression in all animal species examined and these effects constitute a potential risk to humans. TCDD can via binding to the intracellular aryl hydrocarbon receptor (AhR), modulate transcription of a number of genes and the aim of this thesis has been to identify such genes, which may explain the mechanisms behind TCDD-mediated immunotoxicity. LÄS MER
2. Immunohepatotoxicity of the persistent environmental pollutants perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS)
Sammanfattning : Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS), manufactured for a variety of industrial and consumer applications, are ubiquitous environmental pollutants. Their accumulation in humans and wildlife raises serious health concerns. Here, we examined the potential effects of PFOA and PFOS on the innate immune system in mice. LÄS MER
Sammanfattning : Background: This thesis describes the effects of smokeless tobacco (ST) and its derivatives on the oral mucosa; the development of, and results of applying a cessation program for snuff users with long and extensive exposure; and the persistent clinical and histomorphological changes after cessation. Methods: Three of the studies were open prospective non-randomized clinical intervention trials using nicotine replacement therapy (NRT) of either 4 mg nicotine chewing gum or 2 mg nicotine lozenges. LÄS MER
Sammanfattning : Arsenic exposure, mainly via drinking water and certain food, is a major public health concern because of its association with various types of cancers and other non-cancer adverse health effects. Worldwide, more than one hundred million people are exposed to elevated levels of arsenic on a regular basis. LÄS MER
5. Immunotoxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related polychlorinated aromatic hydrocarbons in birds
Sammanfattning : .... LÄS MER