Sökning: "8-Tetrachlorodibenzo-p-dioxin"

Visar resultat 1 - 5 av 27 avhandlingar innehållade ordet 8-Tetrachlorodibenzo-p-dioxin.

1. 1. Adseverin – An Immune-Specific Target of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin

   Författare :Camilla Svensson; Lars Wärngård; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicology; 2; 3; 7; 8-Tetrachlorodibenzo-p-dioxin; TCDD; adseverin; aryl hydrocarbon receptor; immunotoxicity; thymus; cytoskeleton; Toxikologi; Toxicology; Toxikologi; Toxicology; toxikologi;

   Sammanfattning : The environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces thymus atrophy and immunosuppression in all animal species examined and these effects constitute a potential risk to humans. TCDD can via binding to the intracellular aryl hydrocarbon receptor (AhR), modulate transcription of a number of genes and the aim of this thesis has been to identify such genes, which may explain the mechanisms behind TCDD-mediated immunotoxicity. LÄS MER

3. 2. Interactions between the environmental pollutant 2,3,7,8- tetrachlorodibenzo-p-dioxin and coxsackievirus infection : Experimental studies in mice

   Författare :Eva Funseth; Uppsala universitet; []
   Nyckelord :Medical sciences; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; infektionssjukdomar; Infectious Diseases;

   Sammanfattning : This thesis focuses on the interactions between 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and infection. A model of human coxsackievirus type B3 (CB3) infection, adapted to A/J mice, was used.The effects on some immune cell populations and host resistance to CB3 infection were studied immediately after TCDD exposure and 3 months later. LÄS MER

4. 3. Studies on the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on vitamin A homeostasis

   Författare :Charlotte Nilsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :TCDD; dioxin; vitamin A; retinoic acid; lecithin:retinol acyltransferase; retinyl ester hydrolysis; retinol-binding protein; kidney; lymph; stellate cell; kinetics; model-based compartmental analysis;

   Sammanfattning : Vitamin A (retinoids) is needed for normal vision, growth, reproduction, cell differentiation, embryonic development, and immune function. Retinoids exert their functions in the same way as classical hormones, as transcription factors acting via nuclear receptors. LÄS MER

5. 4. Immunotoxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related polychlorinated aromatic hydrocarbons in birds

   Författare :Efstathios Nikolaidis; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

   Sammanfattning : .... LÄS MER

7. 5. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on vitamin A storage in rat hepatic stellate cells

   Författare :Annika Hanberg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Dioxin; TCDD; vitamin A; retinoids; lecithin:retinol acyltransferase; absorption; stellate celL hepatic vitamin A accumulation; intestinal lymph collectionDoctoral Thesis 1996 Annika Hanberg;

   Sammanfattning : The polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs), popularly called dioxins, are persistent pollutants with widespread occurrence in the environment as well as in human food and tissues. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), the most toxic dioxin, as well as other dioxin-like compounds induce a broad spectrum of biochemical and toxic effects, many of which occur at extremely low doses or concentrations. LÄS MER