Sökning: "Poly ADP-ribose polymerase"

Visar resultat 6 - 10 av 22 avhandlingar innehållade orden Poly ADP-ribose polymerase.

  1. 6. The role of chromatin in the induction and repair of DNA damage

    Författare :Mats Ljungman; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; DNA damage; Chromatin; Kromatin; DNA;

    Sammanfattning : The role of chromatin in the induction and repair of DNA damage has a dual nature.The constituent proteins of chromatin protect the DNA against the induction of DNAdamage, while at the same time they reduce the accessibility of DNA to repair enzymes. LÄS MER

  3. 7. Transcriptional Silencing in the Imprinted Igf2-H19 Loci: The Mystique of Epigenetics

    Författare :Vasudeva Ginjala; Andreas Paldi; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Imprinting; DNA methylation; IGF2-H19; CTCF; ZFPs; PARP; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi; Genetics; genetik;

    Sammanfattning : Genomic imprinting marks a subset of autosomal loci expressed in parent of origin-dependent monoallelic expression in a non-Mendelian fashion. To restore totipotency and to reset the imprint according to the sex of the individual, the mark must be erased during germline development. LÄS MER

  4. 8. Genomic Imprinting in Development and Evolution

    Författare :Joanne Whitehead; Rolf Ohlsson; Andras Paldi; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi;

    Sammanfattning : Genetic information is encoded by the linear sequence of the DNA double helix, while epigenetic information is overlayed as the packaging of DNA and associated proteins into the chromatin structure. Variations in chromatin structure play a vital role in establishing and maintaining patterns of gene expression during differentiation and development of higher eukaryotes, and disruption of this epigenetic gene regulation can lead to cancer. LÄS MER

  5. 9. Regulation of TGF-β Signaling by Post-Translational Modifications

    Författare :Peter Lönn; Aristidis Moustakas; Carl-Henrik Heldin; Petra Knaus; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TGF-β; Smad; PARP-1; PARG; ALK5; SIK; signal transduction; transcription; post-translational modification; phosphorylation; ubiquitin; ADP-ribosylation; DNA-binding; receptor degradation; Cell and molecular biology; Cell- och molekylärbiologi; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

    Sammanfattning : Transforming growth factor-β (TGF-β) signaling is initiated when the ligand binds to type II and type I serine/threonine kinase receptors at the cell surface. Activated TGF-β type I receptors phosphorylate R-Smads which relocate, together with co-Smads, to the cell nucleus and regulate transcription. LÄS MER

  7. 10. Immunoregulation by mononuclear phagocytes. Mechanisms and clinical implications

    Författare :Ana Romero; Göteborgs universitet; []
    Nyckelord :;

    Sammanfattning : The cytotoxic effector lymphocytes of the immune system, the natural killer (NK) cells and the CD8+ T lymphocytes (CTL), have been ascribed a pivotal role in defense against malignancy. However, the function of these cells is frequently compromised, in particular at sites of malignant cell expansion. LÄS MER