Sökning: "Mats Ljungman"

Hittade 4 avhandlingar innehållade orden Mats Ljungman.

  1. 1. Radiation induced biomarkers of individual sensitivity to radiation therapy

    Författare :Sara Skiöld; Mats Harms-Ringdahl; Siamak Haghdoost; Mats Ljungman; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; low dose ionizing radiation; radiation sensitivity; proteomics; whole blood; 8-oxo-dG; oxidative stress; acute adverse healthy tissue effects; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : Fifty percent of solid cancers are treated with radiation therapy (RT). The dose used in RT is adjusted to the most sensitive individuals so that not more than 5% of the patients will have severe adverse healthy tissue effects. LÄS MER

  3. 2. Induction of apoptosis in relation to chromatin structure and inhibition of replication by DNA damage from ionizing radiation

    Författare :Jesper Torudd; Mats Harms-Ringdahl; Mats Ljungman; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ionizing radiation; DNA-loop; replication fork; Toxicology; Toxikologi;

    Sammanfattning : The theme of this thesis has been chromatin organization ranging from methodological studies to involvement in apoptotic response. The aims have been: (i) to compare the information obtained by the AVTD method and comet assay concerning DNA-loop organization, (ii) to test the hypothesis that DNA-loop relaxation could be the triggering signal for induction of apoptosis in G0-lymphocytes, and (iii) to study the dose response for inhibition of the replication fork movement and pathways for the DNA repair process at the replication fork. LÄS MER

  4. 3. The role of chromatin in the induction and repair of DNA damage

    Författare :Mats Ljungman; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; DNA damage; Chromatin; Kromatin; DNA;

    Sammanfattning : The role of chromatin in the induction and repair of DNA damage has a dual nature.The constituent proteins of chromatin protect the DNA against the induction of DNAdamage, while at the same time they reduce the accessibility of DNA to repair enzymes. LÄS MER

  5. 4. Biomarkers for DNA damage in human biomonitoring

    Författare :Natalia Kotova; Dag Jenssen; Jan Grawé; Lilianne Abramsson-Zetterberg; Mats Ljungman; Stockholms universitet; []
    Nyckelord :biomonitoring; biomarkers; DNA damage; cancer; diet; UV-light; molekylärgenetik; Molecular Genetics;

    Sammanfattning : Genomic DNA in humans is constantly exposed to different kinds of damage. Therefore, it is desirable to implement methods for detecting and measuring of inflicted body burden. Human biomonitoring (HBM) can here be a useful tool as a link between environmental exposure and disease outcome. LÄS MER