Sökning: "Pharmaceutical analysis"

Visar resultat 6 - 10 av 290 avhandlingar innehållade orden Pharmaceutical analysis.

  1. 6. Development of LC-MS/MS Methods for the Analysis of Chiral and Achiral Pharmaceuticals and Metabolites in Aqueous Environmental Matrices

    Författare :Victoria K.H. Barclay; Curt Pettersson; Monika Johansson; Niklas Tyrefors; Mohamed Abdel-Rehim; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Environmental water matrices; chiral separation; LC-MS MS; trace analysis; method development; active pharmaceutical ingredients; metabolites; Analytical Pharmaceutical Chemistry; Analytisk farmaceutisk kemi;

    Sammanfattning : This thesis describes the development of liquid chromatography tandem mass spectrometry (LC-MS/MS) methods for the trace analysis of active pharmaceutical ingredients (APIs) and their metabolites in aqueous environmental matrices. The research was focused on the development of chiral LC-MS/MS methods for the analysis of fluoxetine and metoprolol, as well as their chiral metabolites in environmental water samples. LÄS MER

  3. 7. Multivariate Synergies in Pharmaceutical Roll Compaction : The quality influence of raw materials and process parameters by design of experiments

    Författare :Nabil Souihi; Johan Trygg; Jukka Rantanen; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Roll compaction; dry granulation; mannitol; dicalcium phosphate; design of experiments; orthogonal projections to latent structures; critical quality attributes; tablet manufacturing; quality by design; design space; near-infrared chemical imaging; texture analysis; modeling; scale up; instrumented roll; Johanson model;

    Sammanfattning : Roll compaction is a continuous process commonly used in the pharmaceutical industry for dry granulation of moisture and heat sensitive powder blends. It is intended to increase bulk density and improve flowability. LÄS MER

  4. 8. Compression analysis as a tool for technical characterization and classification of pharmaceutical powders

    Författare :Josefina Nordström; Göran Alderborn; Maria Strömme; Katharina Picker-Freyer; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; compaction; compression; granules; Kawakita; mechanical properties; particles; PAT; pharmaceutical powders; tablets; Pharmaceutics; Galenisk farmaci;

    Sammanfattning : There are today strong incentives for an increased understanding of material properties and manufacturing processes to facilitate the development of new technologies in the pharmaceutical industry. The purpose of this thesis was to suggest methods requiring a low sample amount for characterization of technical properties of powders. LÄS MER

  5. 9. Biological fate of ketobemidone in man : synthesis, analysis, metabolism, pharmacokinetics

    Författare :Ulf Bondesson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Sammanfattning : .... LÄS MER

  7. 10. Studies of Micellar Electrokinetic Chromatography as an Analytical Technique in Pharmaceutical Analysis - an Industrial Perspective

    Författare :Karin Stubberud; Brian J. Clark; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Micellar Electrokinetic Chromatography; Pharmaceutical Analysis; Chemometrics; Validation; Mass Spectrometry; Partial-filling technique; Pilocarpine; Ibuprofen; Codeine.; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi; analytisk farmaceutisk kemi; Analytical Pharmaceutical Chemistry;

    Sammanfattning : Studies have been performed to evaluate the use of micellar electrokinetic chromatography (MEKC), one mode of capillary electrophoresis (CE), as an analytical technique in industrial pharmaceutical analysis. The potential for using chemometrics for the optimisation of MEKC methods has also been studied as well as the possibilities of coupling MEKC with mass spectrometry (MS). LÄS MER