Sökning: "Pd beta"

Visar resultat 21 - 25 av 32 avhandlingar innehållade orden Pd beta.

  1. 21. Structure-Dynamics relationship in basalganglia: Implications for brain function

    Författare :Jyotika Bahuguna; Arvind Kumar; Jeanette Kotaleski; Nicholas Mallet; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Computational Modeling; Basal ganglia; network dynamics; Computer Science; Datalogi;

    Sammanfattning : In this thesis, I have used a combination of computational models such as mean field and spikingnetwork simulations to study various sub-circuits of basal ganglia. I first studied the striatum(chapter 2), which is the input nucleus of basal ganglia. LÄS MER

  3. 22. Novel measure of olfactory bulb function in health and disease

    Författare :Behzad Iravani; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Present neuroimaging techniques are capable of recording the neural activity from all over the brain but the olfactory bulb (OB). The OB is the first olfactory processing stage of the central nervous system and the site of insult in several neurological disorders, particularly Parkinson’s disease (PD). LÄS MER

  4. 23. Novel Pincer Complex-Catalyzed Transformations : Including Asymmetric Catalysis

    Författare :Juhanes Aydin; Kálmán J. Szabó; Oleg V. Ozerov; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; pincer; palladium; catalysis; chiral; asymmetric; palladium IV; allylation; aldol; aminoacid; C-H functionalization; cross-coupling; homoallylic; heck reaction; tridentate ligand; Chemistry; Kemi; Organic Chemistry; organisk kemi;

    Sammanfattning : This thesis is focused on the development of new pincer complex-catalyzed transformations. Optimization of the catalytic properties (fine-tuning) was directed to increase the catalytic activity as well as the chemo-, stereo- and enantioselectivity of the complexes. LÄS MER

  5. 24. Microglial cells in Neurodegenerative Diseases. The Role of Galectin-3

    Författare :Antonio Boza Serrano; Neuroinflammation; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; neurosciences; microglia; Galectin-3; Alzheimer disease; Parkinson disease; innate immune system; TLR4; TREM2;

    Sammanfattning : Today, dementia such as, Alzheimer’s disease (AD), vascular diseases and motor neurodegenerative diseases, such as Parkinson’s disease (PD), represent a major public health problem. For instance, PD affect to more than 10 million people worldwide and almost 50 million people are affected by dementia. LÄS MER

  7. 25. Alzheimer disease associated Abeta and gamma-secretase : mitochondrial localization and involvement in cell death

    Författare :Camilla Hansson Petersen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In several neurodegenerative disorders, including Alzheimer disease (AD) and Parkinson disease (PD), protein aggregation is accompanied by mitochondrial dysfunction. An increasing number of proteins found in mitochondria have multiple localizations. LÄS MER