Sökning: "Pathway analysis"

Visar resultat 21 - 25 av 728 avhandlingar innehållade orden Pathway analysis.

1. 21. Integrative Approaches in Shotgun Proteomics : From sample preparation to multifaceted data analysis

   Författare :Mariya Nezhyva; Erik T. Jansson; Per Andrén; Gustaf Christoffersson; Jesper Velgaard Olsen; Uppsala universitet; []
   Nyckelord :bottom-up proteomics; thermal proteome profiling; mass-spectrometry imaging; data analysis; melanocortin receptor; Farmaceutisk vetenskap; Pharmaceutical Science;

   Sammanfattning : Bottom-up proteomics mass-spectrometry gives an opportunity to shed light on var-ious biological aspects/characteristics such as protein composition, its modifications,interactions, and dynamics. Its applications span a wide range of biological sciencesaiming to eventually answer fundamental disease related questions or evaluate drugperformance and predict adverse effects. LÄS MER

3. 22. Statistical and Functional Analysis of Genomic and Proteomic Data

   Författare :Yingchun Liu; Beräkningsbiologi och biologisk fysik - Genomgår omorganisation; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Bioinformatik; biomathematics biometrics; unsupervised classification; Bioinformatics; medical informatics; TGF-beta; linear mixed model; expression data; dye bias; 2D-gel; signaling pathway; regulatory motif; microarray; medicinsk informatik; biomatematik;

   Sammanfattning : High-throughput technologies have led to an explosion in the availability of data at the genome scale. Such data provide important information about cellular processes and causes of human diseases, as well as for drug discovery. Deciphering the biologically relevant results from these data requires comprehensive analytical methods. LÄS MER

4. 23. Mass Spectrometric Analysis of Oxylipins : Application to Cytochrome P450-Dependent Metabolism

   Författare :Tomas Nilsson; Ernst Oliw; Johan Bylund; Mikael Hedeland; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; epoxyalcohols; fatty acids; hydroperoxides; electrospray ionization; ichthyosis; CYP4; linear ion trap; fragmentation mechanism; Pharmaceutical pharmacology; Farmaceutisk farmakologi; Biochemical Pharmacology; Biokemisk farmakologi;

   Sammanfattning : Cytochrome P450 (CYP) family 4 constitutes monoxygenases responsible for hydroxylation of fatty acids and other lipids. For example, CYP4F3 metabolizes leukotrienes and CYP4F8 prostaglandin H. Importantly, six of the twelve CYP4 enzymes are orphans, i.e. LÄS MER

5. 24. Microbial Biofilms in the Bioinformatics Era

   Författare :Kemal Sanli; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; metagenomics; bioinformatics software; microbial biofilms; Next Generation Sequencing; pathway analysis; periphyton; marine biofilms; FANTOM; PACFM; PACFM;

   Sammanfattning : Adverse effects of anthropogenic impact on the environment have become conspicuous in the past century and among others include the gradual increase in the global CO2 levels, the contamination of air, soil and water by toxic chemicals, and the emergence of antimicrobial resistance among pathogenic microbial species. Microorganisms partake in an extreme diversity of activities in the environment, and hence, constitute the prime candidates to be investigated in understanding of the progression and effects of the aforementioned environmental hazard scenarios. LÄS MER

7. 25. Outcomes of Myosin 1C Gene Expression Depletion on Cancer-related Pathways, in Vitro and in Clinical Samples

   Författare :Anna Pfister; Afrouz Behboudi; Sahlgrenska Academy at University of Gothenburg; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MYO1C; myosin 1C; gene expression; pathway analysis; endometrial carcinoma;

   Sammanfattning : The unconventional myosin IC has previously been suggested to be a haploinsufficient tumour suppressor. The mechanism for this action has hitherto been unknown, however, and hence we decided to attempt to elucidate the genes involved. LÄS MER