Sökning: "MYO1C"

Hittade 4 avhandlingar innehållade ordet MYO1C.

  1. 1. Cellular, Molecular and Functional Characterization of the Tumor Suppressor Candidate MYO1C

    Författare :Kittichate Visuttijai; Afrouz Behboudi; Katarina Ejeskär; Anders Oldfors; Volker Haucke; Högskolan i Skövde; Göteborgs universitet; Gothenburg University; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MYO1C; myosin IC; tumor suppressor gene; cancer; tumor; PI3K AKT signaling; Medical sciences; Medicin; MYO1C;

    Sammanfattning : Tumor suppressor genes play a role as a growth regulator and a gatekeeper of a cell. Their inactivation is often detected in malignant tumors. Identification of novel tumor suppressor gene candidates may help to further understand tumorigenesis and aid in the discovery of a new treatment leading toward cure of cancer. LÄS MER

  2. 2. Outcomes of Myosin 1C Gene Expression Depletion on Cancer-related Pathways, in Vitro and in Clinical Samples

    Författare :Anna Pfister; Afrouz Behboudi; Sahlgrenska Academy at University of Gothenburg; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MYO1C; myosin 1C; gene expression; pathway analysis; endometrial carcinoma;

    Sammanfattning : The unconventional myosin IC has previously been suggested to be a haploinsufficient tumour suppressor. The mechanism for this action has hitherto been unknown, however, and hence we decided to attempt to elucidate the genes involved. LÄS MER

  3. 3. Novel Tumor Suppressor Gene Candidates in Experimental Endometrial Carcinoma - From Cytogenetic to Molecular Analysis

    Författare :Carola Hedberg; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :cancer; endometrial cancer; tumor suppressor gene; rat models; Skip; Myo1c;

    Sammanfattning : Endometrial carcinoma (EC) is the most common form of gynecological malignancy, ranking fourth in incidence among tumors diagnosed in women. As is the case with other complex diseases, detailed analyses of the underlying mechanisms of cancer are difficult, due mainly to the genetic heterogeneity of the human population and differences in the environment and lifestyle of individuals. LÄS MER

  4. 4. Gene Expression Patterns in a Rat Model of Human Endometrial Adenocarcinoma

    Författare :Sandra Karlsson; Högskolan i Skövde; Göteborgs universitet; Gothenburg University; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Molecular biology; Molekylärbiologi; Medical sciences; Medicin; rat; complex disease; Endometrial adenocarcinoma; gene expression profiling; cDNA microarrays; candidate genes;

    Sammanfattning : Endometrial cancer develops from the endometrium of the uterus and is the most common pelvic malignancy diagnosed in women in the western society. Similar to all cancer diseases, endometrial cancer is a disorder that results from complex patterns of genetic and epigenetic alterations involved in the malignant transformation. LÄS MER