Sökning: "bottom-up proteomics"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden bottom-up proteomics.

1. 1. Integrative Approaches in Shotgun Proteomics : From sample preparation to multifaceted data analysis

   Författare :Mariya Nezhyva; Erik T. Jansson; Per Andrén; Gustaf Christoffersson; Jesper Velgaard Olsen; Uppsala universitet; []
   Nyckelord :bottom-up proteomics; thermal proteome profiling; mass-spectrometry imaging; data analysis; melanocortin receptor; Farmaceutisk vetenskap; Pharmaceutical Science;

   Sammanfattning : Bottom-up proteomics mass-spectrometry gives an opportunity to shed light on var-ious biological aspects/characteristics such as protein composition, its modifications,interactions, and dynamics. Its applications span a wide range of biological sciencesaiming to eventually answer fundamental disease related questions or evaluate drugperformance and predict adverse effects. LÄS MER

3. 2. Parameterized algorithms for hitting set variants applied to protein identification in shotgun proteomics

   Författare :Leonid Molokov; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Union Editing; Fixed Parameter Tractable; Shotgun proteomics; Hitting Set; Parameterized complexity; Hypergraph; Set Cover;

   Sammanfattning : This work is dedicated to problem of protein identification in bottom-up proteomics, and in particular, in shotgun proteomics. It is aimed on providing a new way of interpretation of peak lists. LÄS MER

4. 3. Protein Mixture Inference as Hitting Set Variants and Linear Algebra Problems

   Författare :Leonid Molokov; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Union Editing; Shotgun proteomics; Parameterized complexity; Protein Inference; Shared Peptides; Set Cover; Hypergraph; Hitting Set; Fixed Parameter Tractable; Protein Quan- ti; Star Editing;

   Sammanfattning : This work is dedicated to the problems of protein inference and quantification in bottom-up proteomics, and, in particular, in shotgun proteomics. We adopt a rather classical approach of representing inference problem as a set cover, where proteins are understood as sets of their observations: peptides' masses or sequences. LÄS MER

5. 4. Proteomics as a multifaceted tool in medicine and environmental assessment

   Författare :Jacob Kuruvilla; Susana Cristobal; Mats Lindahl; Mikael Sigvardsson; Jean Armengaud; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : Proteomics is evolving as a multi-faceted tool for addressing various biochemical and biomedical queries in the field of scientific research. This involves various stages, ranging from sample preparation to data analysis and biological interpretation. LÄS MER

7. 5. Method for measurement of exposure to electrophiles : Strategy for identification and exposure estimation using N-terminal haemoglobin adducts

   Författare :Efstathios Vryonidis; Margareta Törnqvist; Hitesh Motwani; Isabella Karlsson; Marie Pedersen; Gabriele Sabbioni; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Haemoglobin adducts; Electrophilic exposure; LC-MS; Adductomics; Acrylamide; Environmental Sciences; miljövetenskap;

   Sammanfattning : We are exposed to many chemicals in our everyday life. Some of these chemicals could pose risks for our health. To reduce such risks, it is important to know what we are exposed to, how much, and how toxic the chemicals are. LÄS MER