Sökning: "Orphan"

Visar resultat 16 - 20 av 72 avhandlingar innehållade ordet Orphan.

  1. 16. NR4A orphan nuclear receptors in immediate early regulation of retinoid signaling and neuroprotection

    Författare :Nikolaos Volakakis; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : NR4A receptors show distinct properties that make them unique within the family of nuclear receptors. They lack a ligand-binding cavity and a canonical coactivator-binding site and they are induced both in vivo and in vitro in an immediate early way by an extremely wide repertoire of substances/conditions. LÄS MER

  3. 17. Development of sensitive cellular assay systems and their application to the identification of "orphan" seven-transmembrane receptors

    Författare :Knut Kotarsky; Slemhinnans immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biokemi; Metabolism; Biochemistry; metabolism; leukotrieneB4; thiazolidinedione; 9-HODE; fatty acid; luciferase; GFP; reporter gene; preclinical assay; receptor; GPCR;

    Sammanfattning : Seven-transmembrane, G-protein coupled receptors play a central role in physiology since they facilitate cell communication in multicellular organisms by recognition of a broad range of ligands. They also represent important drug targets. LÄS MER

  4. 18. Nuclear hormone receptor signaling in the developing CNS : studies on the retinoid receptors RAR and RXR, and the orphan receptors NURR1, NOR1 and NGFI-B

    Författare :Ludmila Solomin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The nuclear hormone receptor superfamily comprises more than sixty members, including receptors for steroids, thyroid hormone, vitamin D and retinoids. Many nuclear receptors function as ligand-induced transcription factors that upregulate expression of specific target genes. LÄS MER

  5. 19. Regulation of cytochrome P4502C7 : effects of growth hormone and vitamin A

    Författare :Stefan Westin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :P450; growth hormone; vitamin A; gene regulation; orphan receptors;

    Sammanfattning : Members of the CYP2C subfamily, highly represented in rat liver, are constitutively expressed genes that encode enzymes that metabolize endogenous substrates such as steroids. Expression of P4502C11 and P4502C12 in rat liver is regulated in a sex-specific manner that ultimately depends on the sexually differentiated secretory pattern of GH release. LÄS MER

  7. 20. On retinoid receptors, Nurr1 and related transcription factors in the CNS

    Författare :Rolf H Zetterström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Nurr1; NGFI-B; Nor1; RAR; RXR; CRBP; CRABP; substantia nigra; basal ganglia; dopamine; orphan receptor; vitamin A; retinoic acid; transcription factor;

    Sammanfattning : It has long been known that retinoids (vitamin A derivatives) are required for normal development and growth; in excess however metabolites such as all-trans retinoic acid are potent teratogens. Retinoids exert their effects through transcription factors known as the retinoic acid receptors (RARam -ß and -y) and retinoid X receptors (RXRa, -ß and -y). LÄS MER