Sökning: "RAR"

Visar resultat 1 - 5 av 31 avhandlingar innehållade ordet RAR.

  1. 1. Nuclear hormone receptor signaling in the developing CNS : studies on the retinoid receptors RAR and RXR, and the orphan receptors NURR1, NOR1 and NGFI-B

    Författare :Ludmila Solomin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The nuclear hormone receptor superfamily comprises more than sixty members, including receptors for steroids, thyroid hormone, vitamin D and retinoids. Many nuclear receptors function as ligand-induced transcription factors that upregulate expression of specific target genes. LÄS MER

  3. 2. Retinoids and vitamin D in skin and parathyroid glands

    Författare :Liu Wei; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; all-trans retinoic acid 9-cis retinoic acid vitamin A. vitamin D. CRBP. CRABP. RAR. RXR. parathyroid hormone. calcium receptor; Kirurgi; Surgery; Kirurgi; Surgery; kirurgi;

    Sammanfattning : Vitamin D3 (VitD3) and retinoids are important factors involved in differentiation and proliferation in many cell systems. Their effects in skin, where retinoids and vitamin D are known to be crucially involved in keratinocyte differentiation and function,, and in the parathyroid, the overall regulatory organ in calcium homeostasis were studied. LÄS MER

  4. 3. On retinoid receptors, Nurr1 and related transcription factors in the CNS

    Författare :Rolf H Zetterström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Nurr1; NGFI-B; Nor1; RAR; RXR; CRBP; CRABP; substantia nigra; basal ganglia; dopamine; orphan receptor; vitamin A; retinoic acid; transcription factor;

    Sammanfattning : It has long been known that retinoids (vitamin A derivatives) are required for normal development and growth; in excess however metabolites such as all-trans retinoic acid are potent teratogens. Retinoids exert their effects through transcription factors known as the retinoic acid receptors (RARam -ß and -y) and retinoid X receptors (RXRa, -ß and -y). LÄS MER

  5. 4. Functional studies on the orphan receptor Nurr1 and related retinoid receptors

    Författare :Diogo Sampaio e Castro; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Nuclear receptors (NRs) constitute a large family of ligand-inducible transcription factors which includes receptors for steroid hormones, retinoids (vitamin A derivatives), vitamin D an d thyroid hormone. The family also includes a large number of structurally related proteins that lack identified ligands and are therefore refered to as orphan receptors. LÄS MER

  7. 5. Cyclin A1 Expression and Regulation in Hematopoietic and Leukemic Cells

    Författare :Jenny Ekberg; Malmö Patologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; General pathology; pathological anatomy; Patologi allmän ; patologisk anatomi; onkologi; Cytologi; cancerology; oncology; Cytology; AML; cyclin A1; apoptosis; cell cycle regulation;

    Sammanfattning : Increased expression of the cell cycle regulatory protein cyclin A1 has previously been detected in patients with acute myeloid leukemia (AML) and targeted overexpression of cyclin A1 in a transgenic mouse model initiated AML. The aim of this thesis was to further study the expression and regulation of cyclin A1 in hematopoietic cells. LÄS MER