Sökning: "CRABP"
Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet CRABP.
1. Alcohol and gene expression in nerve cells with emphasis on transcription factor AP-1
Sammanfattning : Alcohol induces profound effects on the function of the nerve cells in the nervous system. Alterations in gene expression is an important way by which these effects could be induced and sustained. Activating Protein-1 (AP-1) is a dimeric transcription factor constituted of proteins from the fos and jun immediate-early gene families. LÄS MER
2. Retinoids and vitamin D in skin and parathyroid glands
Sammanfattning : Vitamin D3 (VitD3) and retinoids are important factors involved in differentiation and proliferation in many cell systems. Their effects in skin, where retinoids and vitamin D are known to be crucially involved in keratinocyte differentiation and function,, and in the parathyroid, the overall regulatory organ in calcium homeostasis were studied. LÄS MER
3. On retinoid receptors, Nurr1 and related transcription factors in the CNS
Sammanfattning : It has long been known that retinoids (vitamin A derivatives) are required for normal development and growth; in excess however metabolites such as all-trans retinoic acid are potent teratogens. Retinoids exert their effects through transcription factors known as the retinoic acid receptors (RARam -ß and -y) and retinoid X receptors (RXRa, -ß and -y). LÄS MER
4. Studies on cellular vitamin A metabolism and effects of UV irridation in human keratinocytes and melanocytes
Sammanfattning : Reinoids (vitamin A and its derivatives) are modulators of proliferation and differentiation in a variety of cell types, including epidermal cells. Both retinol (ROH) and its metabolite 3,4-didehydroretinol (ddROH) can be converted to the acid form retinoic acid (RA) and 3,4-didehydroretinoic acid (ddRA), ligands for the nuclear receptors inducing gene transcriptions. LÄS MER
5. Vitamin A and ß-carotene metabolism and effects of UV irradiation in human keratinocytes and melanocytes
Sammanfattning : Retinoids (vitamin A and its derivatives) are modulators of proliferation and differentiation. Both retinol (ROH) and its metabolite 3,4-didehydroretinol (ddROH) can be converted to retinoic acid (RA) and 3,4-didehydroretinoic acid (ddRA), ligands for the nuclear receptors, which induce gene transcriptions. LÄS MER