Sökning: "Orphan"

Visar resultat 21 - 25 av 72 avhandlingar innehållade ordet Orphan.

  1. 21. Causes of Substitution Frequency Variation in Pathogenic Bacteria

    Författare :Wagied Davids; Siv Andersson; Otto Berg; Bengt Persson; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biology; Comparative genomics; Molecular evolution; Bioinformatics; Human pathogens; Rickettsia; Helicobacter pylori; Biologi; Biology; Biologi;

    Sammanfattning : Estimating substitution frequencies at sites that influence (Ka) and do not influence (Ks) the amino acid sequence is important for understanding the dynamics of molecular sequence evolution and the selective pressures that have shaped genetic variation. The aim of this work was to gain a deeper understanding of the driving forces of substitution frequency variation in human pathogens. LÄS MER

  3. 22. Some aspects of nuclear receptor function in the CNS : novel roles of Nurr1 and RXR in developing and mature neurons

    Författare :Åsa Wallén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The nuclear receptor superfamily comprises the receptors for steroid hormones, thyroid hormone, vitamin D and retinoids. The family also includes a number of receptors that lack identified ligands, and are therefore referred to as orphan receptors. LÄS MER

  4. 23. Modulation of nuclear receptor activity by a unique class of corepressors

    Författare :Elin Holter; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Nuclear receptors; corepressors; transcription; intracellular localization.;

    Sammanfattning : Nuclear receptors comprise a unique family of transcription factors that are crucial regulators of gene expression involved in diverse physiological and developmental processes. The nuclear receptor field has undergone a very rapid development during the recent two decades due to the recognition of the importance of nuclear receptors as intracellular signal transmitters and pharmaceutical targets. LÄS MER

  5. 24. Characterization of habenular neurocircuitry. A potential novel target for treating depression

    Författare :Jonas Jester-Broms; Enheten för psykiatrisk neuromodulering (PNU); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : In the last decade, there has been an explosion of interest within the psychiatric research community in a small diencephalic brain region called the habenula. It has been uncovered as a key regulator of monoaminergic transmission, playing a fundamental role in decision making, behavioral flexibility, inhibitory control, sleep, pain and analgesia. LÄS MER

  7. 25. Functional studies on the nuclear receptor Nurr1

    Författare :Mariette Nordzell; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The nuclear receptor (NR) superfamily comprises the largest family of ligand-activated transcription factors in eukaryotes, and it plays critical roles in many aspects of vertebrate development and physiology. The NR family is well conserved throughout evolution, and is found in organisms as diverse as nematodes, flies and mammals. LÄS MER