Sökning: "Organisk kemi su"
Visar resultat 1 - 5 av 324 avhandlingar innehållade orden Organisk kemi su.
1. Investigating polymorphism in small molecules using three-dimensional electron diffraction
Sammanfattning : For scientific, regulatory and intellectual property reasons, the discovery and characterisation of polymorphic systems is an integral aspect of the development process of any solid-formulated drug product. Yet, these studies are often hindered by crystal quality and size, poor yields and the generation of mixtures of phases. LÄS MER
2. Synthesis of Organofluorine Compounds and Allenylboronic Acids - Applications Including Fluorine-18 Labelling
Sammanfattning : This work is focused on two areas: the chemistry of organofluorine and organoboron compounds. In the first chapter, a copper-catalysed synthesis of tri- and tetrasubstituted allenylboronic acids is presented. Extension of the same method leads to allenylboronic esters. LÄS MER
3. Computer-Assisted Carbohydrate Structural Studies and Drug Discovery
Sammanfattning : Carbohydrates are abundant in nature and have functions ranging from energy storage to acting as structural components. Analysis of carbohydrate structures is important and can be used for, for instance, clinical diagnosis of diseases as well as in bacterial studies. The complexity of glycans makes it difficult to determine their structures. LÄS MER
4. Synthesis of oligosaccharides related to the capsular polysaccharides of Streptococcus pneumoniae serotype 9 and of Cryptococcus neoformans
Sammanfattning : In the present investigation, synthesis of oligosaccharides corresponding to structural elements present in the capsular polysaccharides of Streptococcus pneumoniae and Cryptococcus neoformans has been achieved. The first two sections describe the synthesis of spacer-equipped oligosaccharides corresponding to structures from the CPS of Streptococcus pneumoniae serotypes 9N, 9A and 9L, the production of which involved synthetic challenges such as the construction of β-ManNAc and α-GlcA linkages. LÄS MER
5. Studies of oligosaccharides and carbon-13 enriched bacterial polysaccharides using NMR spectroscopy and computer simulations
Sammanfattning : The conformation and dynamics of the trisaccharide methyl β-D-Glcp-(1--> 2)[β-D-Glcp-(1 --> 3)] α-D-Manp and its constituent disaccharides methyl β-D-Glcp-(1 --> 2) α-D-Manp and methyl β-D-Glcp-(1 --> 3) α-D-Manp have been studied using computer simulations and NMR spectroscopy. The computer simulations applied were Metropolis Monte Carlo simulations employing the HSEA force field and Langevin dynamics simulations using the PARM22 and CHEAT95 force fileds. LÄS MER
