Sökning: "electrophilic"

Visar resultat 1 - 5 av 90 avhandlingar innehållade ordet electrophilic.

  1. 1. Synthesis of Organofluorine Compounds and Allenylboronic Acids - Applications Including Fluorine-18 Labelling

    Författare :Denise N. Meyer; Kálmán J. Szabó; Dominique Cahard; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; boron; allenylboronic acid; BINOL; homopropargyl alcohol; organocatalyst; organoboron; organofluorine; fluorine; fluorine-18; late-stage; labelling; labeling; nucleophilic; electrophilic; fluorination; positron emision tomography; PET; radiotracer; hypervalent iodine; benziodoxole; benzoxazepines; diaryliodonium salt; metal-free; neutrophil elastase; NE; neutrophil elastase inhibitor; trifluoromethylation; trifluoromethylthiolation; difluoro enol silyl ethers; organisk kemi; Organic Chemistry;

    Sammanfattning : This work is focused on two areas: the chemistry of organofluorine and organoboron compounds. In the first chapter, a copper-catalysed synthesis of tri- and tetrasubstituted allenylboronic acids is presented. Extension of the same method leads to allenylboronic esters. LÄS MER

  3. 2. Development of new Fluorination Methods Directed to Fluorine-18 Labelling

    Författare :Miguel Ángel Cortés González; Kálmán J. Szabó; Guosheng Liu; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; fluorine; fluorine-18; late-stage; labelling; nucleophilic; electrophilic; fluorination; positron emision tomography; PET; hypervalent iodine; benziodoxole; metal-free; DBU; copper; palladium; rhodium; carbene; organisk kemi; Organic Chemistry;

    Sammanfattning : This thesis deals with the development of new fluorination reactions and their application to fluorine-18 labelling. Fluorine-18 labelled compounds are employed as tracers in Positron Emission Tomography (PET), which is a powerful non-invasive imaging method in medical diagnostics. LÄS MER

  4. 3. On the mechanism of electrophilic aromatic substitution : an investigation by means of the effect of isotopic mass on reaction velocity

    Författare :Lars Melander; Stockholms högskola; []
    Nyckelord :;

    Sammanfattning : .... LÄS MER

  5. 4. Development of Palladium-Catalyzed Transformations Involving η1-Allypalladium Species

    Författare :Niclas Solin; Kálmán Szabó; Antonio M. Echavarren; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Palladium; Homogenous catalysis; Allylation; Electrophilic substitution; Density functional calculations; Organic chemistry; Organisk kemi;

    Sammanfattning : This thesis is focused on investigation of the structure, reactivity and isomerization reactions of η1-allylpalladium complexes, which are key intermediates in catalytic transformations. The first part of this thesis concerns the structure and reactivity of bis-allylpalladium complexes. LÄS MER

  7. 5. Transition Metal-Free O-, N- and S-Arylations with Diaryliodonium Salts

    Författare :Gabriella Kervefors; Berit Olofsson; Boris Nachtsheim; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Amines; hypervalent iodine; electrophilic arylation; methodology development; total synthesis; organisk kemi; Organic Chemistry;

    Sammanfattning : This thesis concerns the development of metal-free arylation procedures using diaryliodonium salts, a non-toxic and versatile electrophilic arylating reagent, with applications to synthesize biologically relevant targets.The first part describes a transition metal-free formal synthesis of phenoxazine with an O-functionalization of a certain phenol as a key step. LÄS MER