Sökning: "late-stage"

Visar resultat 1 - 5 av 145 avhandlingar innehållade ordet late-stage.

  1. 1. Iridium-Catalyzed C−H Activation Methods for Late-Stage Functionalization of Pharmaceuticals

    Författare :Erik Weis; Belén Martín‐Matute; Jin-Quan Yu; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; amination; catalysis; C-H activation; C-H functionalization; high-throughput experimentation; iodination; iridium; isotope labelling; late-stage functionalization; methylation; Organic Chemistry; organisk kemi;

    Sammanfattning : C-H activations have over the recent decades risen from a mere curiosity to a viable synthetic strategy. However, challenges in terms of accessible transformations, selectivity and functional group tolerance limit the widespread applicability of this approach. LÄS MER

  3. 2. Oral eflornithine treatment of late-stage human African trypanosomiasis

    Författare :Mikael Boberg; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Sleeping Sickness; Neglected Tropical Diseases; Enantiomers; Nonlinear Mixed Effects Modeling; Pharmacokinetics; Pharmacodynamics;

    Sammanfattning : Human African trypanosomiasis is a fatal disease unless treated. It is a parasitic vector borne disease endemic in sub-Saharan African countries. Eflornithine is a recommended treatment for gambiense human African trypanosomiasis (g-HAT) in the later disease stage when the parasites have infected the central nervous system. LÄS MER

  4. 3. Towards a better care for late stage Parkinson's disease

    Författare :Kristina Rosqvist; Lund Neurologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : .... LÄS MER

  5. 4. Development of new Fluorination Methods Directed to Fluorine-18 Labelling

    Författare :Miguel Ángel Cortés González; Kálmán J. Szabó; Guosheng Liu; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; fluorine; fluorine-18; late-stage; labelling; nucleophilic; electrophilic; fluorination; positron emision tomography; PET; hypervalent iodine; benziodoxole; metal-free; DBU; copper; palladium; rhodium; carbene; organisk kemi; Organic Chemistry;

    Sammanfattning : This thesis deals with the development of new fluorination reactions and their application to fluorine-18 labelling. Fluorine-18 labelled compounds are employed as tracers in Positron Emission Tomography (PET), which is a powerful non-invasive imaging method in medical diagnostics. LÄS MER

  7. 5. Late-stage 11C-carbonylation of drug-like molecules for PET

    Författare :Kaisa Horkka; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Positron emission tomography (PET) is a non-invasive in vivo imaging technique used for translational biomedical research and clinical diagnosis. A fundamental pre-condition for PET is the radiolabelled tracer molecule used in the emission measurement, and there is a pressing need to accelerate the development of novel PET tracers to meet an increasing demand from the healthcare system, academia and drug industry. LÄS MER