Sökning: "small molecule"

Visar resultat 1 - 5 av 523 avhandlingar innehållade orden small molecule.

  1. 1. Modeling normal and malignant hematopoiesis in vitro. To screen for extrinsic regulators and differentiation therapy

    Författare :Simon Hultmark; Avdelningen för molekylärmedicin och genterapi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; acute myeloid leukaemia; Hematologi; stem cells; differentiation induction; leukaemia; treatment; small molecule drugs; PKC; FLT3; shRNA; small molecule inhibitor; Small Molecule Libraries; MEK ERK pathway; natural product; co-culture; drug screening; combination therapy;

    Sammanfattning : The incredible thing with blood stem cells, also known as hematopoietic stem cells (HSC), is that they can restore normal hematopoiesis in patients that need a new blood system. Since a prerequisite for successful transplantation is immune compatibility, it requires large donor registries to find a suitable match for a recipient. LÄS MER

  2. 2. Design, Synthesis and Characterization of Small Molecule Inhibitors and Small Molecule : Peptide Conjugates as Protein Actors

    Författare :Jonas Nilsson; Lars Baltzer; Ingemar Kvarnström; Thomas Olsson; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Synthetic receptor; Peptide inhibitor conjugate; Peptide protein surface interactions; General Lead Discovery Library; Combinatorial Chemistry; Solid Phase Chemistry; Targeted Library; Thrombin inhibitor; Fluorescence; Surface Plasmon Resonance; Organic chemistry; Organisk kemi;

    Sammanfattning : This thesis describes different aspects of protein interactions. Initially the function of peptides and their conjugates with small molecule inhibitors on the surface of Human Carbonic Anhydrase isoenzyme II (HCAII) is evaluated. LÄS MER

  3. 3. Small Molecule Diffusion in Spherulitic Polyethylene : Experimental Results and Simulations

    Författare :Alessandro Mattozzi; Ulf W. Gedde; Alan H. Windle; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; diffusion; polyethylene; poly ethylene-co-octene ; free volume; morphology; intermediate phase; spherulite; Monte Carlo simulation; Polymer chemistry; Polymerkemi;

    Sammanfattning : The diffusion of small-molecule penetrants in polyethylene is hindered by impenetrable crystals and by the segmental constraints imposed by the crystals on the penetrable phase. Liquid and vapour n-hexane sorption/desorption measurements were performed on metallocene catalyzed homogenous poly(ethylene-co-octene)s. LÄS MER

  4. 4. Small molecule diffusion in spherulitic polyethylene : experimental results and simulations

    Författare :Alessandro Mattozzi; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Polymer chemistry; Polymerkemi;

    Sammanfattning : .... LÄS MER

  5. 5. Investigating polymorphism in small molecules using three-dimensional electron diffraction

    Författare :Molly Lightowler; Xiaodong Zou; Hosea M. Nelson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; 3D electron diffraction; structure determination; polymorphism; crystallisation; phase identification; small molecule; oorganisk kemi; Inorganic Chemistry;

    Sammanfattning : For scientific, regulatory and intellectual property reasons, the discovery and characterisation of polymorphic systems is an integral aspect of the development process of any solid-formulated drug product. Yet, these studies are often hindered by crystal quality and size, poor yields and the generation of mixtures of phases. LÄS MER