Sökning: "Niclas jonsson"
Visar resultat 1 - 5 av 9 avhandlingar innehållade orden Niclas jonsson.
1. Methodological studies on non-linear mixed effects model building
Sammanfattning : Population analysis of pharmacokinetic/pharmacodynamic (PK/PD) data by the use of non-linear mixed effects modeling offers a number of benefits over traditional methods of analyzing this type of data. These benefits include the possibility to appropriately characterize the typical PK/PD behaviour in the population as well as the associated variability when only a few observations are available for each individual. LÄS MER
2. Mellan tradition och förnyelse : Utmaningar i religionsläraruppdraget
Sammanfattning : The current assignment of religious studies teachers is grounded on a confession-free foundation, expressed through the values of Swedish society. However, the subject still carries traces of a confessional tradition. Up until recently, Christianity played a major role in both teaching and teacher assignments. LÄS MER
3. Role of the Blood-Brain Barrier in Stereoselective Distribution and Delay in H1 Receptor Occupancy of Cetirizine in the Guinea Pig Brain
Sammanfattning : Cetirizine, an H1-antihistamine, is prescribed for allergic disorders. It exists as a racemic mixture, with levocetirizine being the active enantiomer. The central nervous system side-effects of H1-antihistamines are caused by their penetration into the brain. LÄS MER
4. Pharmacometric Models for Individualisation of Warfarin in Adults and Children
Sammanfattning : Warfarin is one of the most widely used anticoagulants. Therapy is complicated by warfarin’s narrow therapeutic range and pronounced variability in individual dose requirements. Although warfarin therapy is uncommon in children, it is crucial for children with certain congenital or acquired heart diseases. LÄS MER
5. Benefits of Pharmacometric Model-Based Design and Analysis of Clinical Trials
Sammanfattning : Quantitative pharmacokinetic-pharmacodynamic and disease progression models are the core of the science of pharmacometrics which has been identified as one of the strategies that can make drug development more effective. To adequately develop and utilize these models one needs to carefully consider the nature of the data, choice of appropriate estimation methods, model evaluation strategies, and, most importantly, the intended use of the model. LÄS MER