Sökning: "NMDA receptor"

Visar resultat 31 - 35 av 126 avhandlingar innehållade orden NMDA receptor.

1. 31. Neuromodulation within a spinal locomotor network : role of metabotropic glutamate receptor subtypes

   Författare :Petronella Kettunen; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :mGluR1; mGluR5; spinal cord; modulation; glutamate; NMDA; leak channel; locomotion; endocannabinoids; lamprey.;

   Sammanfattning : The metabotropic glutamate receptors, mGluRs, are G-protein coupled receptors. They consist of eight cloned subtypes, which are divided into three groups depending on the amino acid sequence similarity, pharmacology and their signal pathways. LÄS MER

3. 32. Experimental studies of N-methyl-D-aspartate receptor NR3 subunits

   Författare :Anna Öhman; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : This thesis focuses on the NR3A and NR3B subunits of the excitatory glutamate receptor N-methyl-D-aspartate (NMDA). Functional NMDA receptors are believed to be tetrameric complexes with combinations of NR1 and NR2 subunits, and possible addition of NR3 subunits. LÄS MER

4. 33. Development of in vitro and ex vivo positron-emitting tracer techniques and their application to neurotrauma

   Författare :Sven Sihver; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Short-lived radionuclides; in vitro receptor binding; in vitro and ex vivo autoradiography; positron emission tomography; benzodiazepine; muscarinic acetylcholine; and NMDA receptors in CNS; experimental neurotrauma; Neurovetenskap; Neurology; Neurologi; medicinsk farmakologi; Medical Pharmacology;

   Sammanfattning : The use of positron-emitting tracers has been extended beyond tomographic facilities in the last few years, giving rise to a general positron-emitting tracing technique. The methodological part of the present thesis involved the evaluation of the performance of storage phosphor (SP) plates, with tracers labeled with high-energy, short-lived, positron-emitting radionuclides, using homogenized tissue specimens and autoradiography with frozen brain sections. LÄS MER

5. 34. Physiopathological aspects of NMDA transmission in the basal ganglia : in vitro and in vivo release studies

   Författare :Michele Morari; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :basal ganglia; NMDA; dizocilpine; microdialysis; slices; synaptosomes; dopamine; acetylcholine; glutamate; GABA; 6OH-dopamine;

   Sammanfattning : N-methyl-D-aspartic acid (NMDA) is an excitatory amino acid selectively acting on a subclass of glutamate receptors (the NMDA ionotropic receptor) which has been involved in many of the physiological and pathological effects of glutamate in the CNS. The basal ganglia are particularly enriched in NMDA receptors and NMDA receptor activation in the basal ganglia has been involved in the expression of motor behaviour. LÄS MER

7. 35. Synthesis and structure activity relationships of competitive NMDA antagonists with analgesic activity

   Författare :Britt-Marie Swahn; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; Organic Pharmaceutical Chemistry; organisk farmaceutisk kemi;

   Sammanfattning : The compounds cis-3-(1-oxo-2-phosphonoethyl)-2-piperidinecarboxylic acid 1 and cis-3-(1-hydroxy-2-phosphonoethyl)-2-piperidinecarboxylic acid 2 were synthesized and found to be potent N-methyl-D-aspartate (NMDA) antagonists. NMR analysis showed that 1 prefers a 2eq,3ax chair conformation probably due to a conformer-stabilizing internal hydrogen bond. LÄS MER