Sökning: "endocannabinoids"

Visar resultat 1 - 5 av 15 avhandlingar innehållade ordet endocannabinoids.

  1. 1. Endocannabinoids and Related Lipids in Chronic Pain : Analytical and Clinical Aspects

    Författare :Niclas Stensson; Bijar Ghafouri; Björn Gerdle; Nazdar Ghafouri; Christopher Fowler; Per-Johan Jakobsson; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : In Europe, approximately one in five adults experience chronic pain, pain that lasts more than three months. Chronic pain is a significant problem not only for those people suffering from chronic pain but also for society. The prevalence of chronic pain is higher in women and lower socioeconomic groups. LÄS MER

  3. 2. Endocannabinoids and N-acylethanolamines in translational pain research : from monoacylglycerol lipase to muscle pain

    Författare :Nazdar Ghafouri; Christopher J Fowler; Andrew SC Rice; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Monoacylglycerol lipase; endocannabinoid; palmitoylethanolamide; N-acylethanolamines; microdialysis; chronic widespread pain; muscle pain; trapezius;

    Sammanfattning : In the early nineties cannabinoid receptors, the main target for Δ9-tetrahydrocannabinol (THC), the psychoactive component of marijuana were identified. Shortly after their endogenous ligands, N-arachidonoylethanolamine (anandamide, AEA) and 2-diacylglycerol (2-AG) were characterized. LÄS MER

  4. 3. Neuromodulation via endocannabinoids and nitric oxide in the lamprey spinal cord

    Författare :Alexandros Kyriakatos; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The overall objective of this thesis is to increase our understanding of neural networks generating locomotion. These networks called Central Pattern Generators (CPG), are localized in the spinal cord and can generate the basic locomotor pattern in the absence of sensory or supraspinal inputs. LÄS MER

  5. 4. In the right place and at the right time : cellular and functional neuroanatomy of endocannabinoids and neuropeptides

    Författare :Joanne Bakker; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : A plethora of chemical signals, including endocannabinoids and neuropeptides, enable neuronal communication beyond the classical neurotransmitters. Many of these molecules are also expressed during (early) brain development, helping neurons to mature and neuronal circuits to take form. LÄS MER

  7. 5. Neuromodulation within a spinal locomotor network : role of metabotropic glutamate receptor subtypes

    Författare :Petronella Kettunen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :mGluR1; mGluR5; spinal cord; modulation; glutamate; NMDA; leak channel; locomotion; endocannabinoids; lamprey.;

    Sammanfattning : The metabotropic glutamate receptors, mGluRs, are G-protein coupled receptors. They consist of eight cloned subtypes, which are divided into three groups depending on the amino acid sequence similarity, pharmacology and their signal pathways. LÄS MER