Sökning: "NMDA receptor"

Visar resultat 41 - 45 av 126 avhandlingar innehållade orden NMDA receptor.

  1. 41. Nicotinic effects on midbrain dopamine neurons : a dual mechanism of action

    Författare :Björn Schilström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :nicotine; dopamine; ventral tegmental area; glutamate; microdialysis; Fos expression; NMDA receptor; presynaptic;

    Sammanfattning : The neurons of the mesocorticolimbic dopamine system are located in the ventral tegmental area (VTA) in the mesencephalon and send their projections to forebrain structures, such as the prefrontal cortex, the amygdala and the nucleus accumbens. The dopamine system is important in regulating mood and motivation as well as cognitive function and appear to be primarily involved in drug dependence, since most drugs abused by man stimulate this system. LÄS MER

  3. 42. Pathophysiology of subarachnoid hemorrhage in the rat

    Författare :Giselle F Prunell dos Santos; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Apoptosis; cell death; cerebral blood flow; cerebral metabolism; inflammation; NMDA receptor subunits; subarachnoid hemorrhage.;

    Sammanfattning : Subarachnoid hemorrhage (SAH) causes brain damage, but the underlying mechanisms are poorly understood. An obstacle in SAH research is the lack of an adequate animal model. In this thesis, we developed a new approach to simulate SAH that involves the injection of blood into the prechiasmatic cistern of the rat. LÄS MER

  4. 43. Importance of endogenous kynurenic acid in brainm catecholaminergic processes and in the pathophysiology of schizophrenia

    Författare :Sophie Erhardt; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Schizophrenia; kynurenic acid; nicotine; VTA; dopamine; NMDA-receptors;

    Sammanfattning : Kynurenic acid is a metabolite of tryptophan and the only known naturally occurring NMethylD-Aspartic acid (NMDA)-receptor antagonist (at the co-agonist glycine site) in the human brain. The aim of the present work was to investigate the physiological and pharmacological significance of endogenous kynurenic acid as well as its putative pathophysiological implications. LÄS MER

  5. 44. Schizophrenia and Nitric Oxide: Deficits in Information Processing Invetigated in Animal Models

    Författare :Daniel Klamer; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; phencyclidine – nitric oxide – prepulse inhibition – habituation – acoustic startle – cAMP – in vivo microdialysis – NMDA receptor – rat – mouse – schizophrenia;

    Sammanfattning : Rationale: Schizophrenia-like symptoms can be induced in humans by phencyclidine (PCP), a non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor. Schizophrenic patients and PCP-treated animals display deficits in pre-attentive information processing, as assessed by e.g. prepulse inhibition of the acoustic startle response. LÄS MER

  7. 45. Genomic clues to secondary injury mechanisms in brain trauma

    Författare :Christina von Gertten; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :traumatic brain injury; cerebral cortical contusion; weight-drop model; depolarisation; gene expression; nestin; MMP-9; TIMP-1; osteopontin; CD44; hippocalcin; NMDA receptor; microarray; rat;

    Sammanfattning : Traumatic brain injury (TBI) is a heterogenous disease that can lead to persistent disability or death. The immediate mechanical disruption of brain tissue is followed by a phase of secondary brain injury. During this phase TBI challenges clinical interventions due to its complexity. LÄS MER