Sökning: "experimental neurotrauma"

Hittade 4 avhandlingar innehållade orden experimental neurotrauma.

  1. 1. Assessment of experimental neurotrauma

    Författare :Ying-Lai Huang; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Impulse noise; diffuse brain injury; focal brain injury; closed head injury; NSE; S-100; GFAP; apoptosis; astrocytosis; glutamate; c-JUN; rotational acceleration; CSF;

    Sammanfattning : Model systems of closed head injury are designed to replicate aspects of traumatic brain injury, ischemia and epilepsy in man. The aim of this thesis was to (1) develop sensitive systems enabling analyses of the biochemical reactions, as reflected by leakage of marker compounds to the cerebrospinal fluid (CSF); and (2) develop and assess a new model for closed head injury and associated dynamic changes in the brain cell. LÄS MER

  3. 2. Development of in vitro and ex vivo positron-emitting tracer techniques and their application to neurotrauma

    Författare :Sven Sihver; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Short-lived radionuclides; in vitro receptor binding; in vitro and ex vivo autoradiography; positron emission tomography; benzodiazepine; muscarinic acetylcholine; and NMDA receptors in CNS; experimental neurotrauma; Neurovetenskap; Neurology; Neurologi; medicinsk farmakologi; Medical Pharmacology;

    Sammanfattning : The use of positron-emitting tracers has been extended beyond tomographic facilities in the last few years, giving rise to a general positron-emitting tracing technique. The methodological part of the present thesis involved the evaluation of the performance of storage phosphor (SP) plates, with tracers labeled with high-energy, short-lived, positron-emitting radionuclides, using homogenized tissue specimens and autoradiography with frozen brain sections. LÄS MER

  4. 3. Prevention and prediction of head and neck injury in traffic accidents - using experimental and numerical methods

    Författare :Peter Halldin; KTH; []
    Nyckelord :Head injuries; neck injuries; prevention; roll-over; motorcycle; helmet;

    Sammanfattning : Injuries to the head and neck system are potentially amongthe most serious injuries in humans, since they may damage thespinal cord. It is therefore important to develop safetysystems that can prevent injuries to the neuro- system, therebyreducing human suffering and costs to society. LÄS MER

  5. 4. Coagulation and inflammation in experimental endotoxemia in vitro and in vivo : monitoring method and effects of nicotinamide

    Författare :Johanna S Ungerstedt; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Sepsis; endotoxin; tissue factor; cytokines; nicotinamide; coagulation; inflammation;

    Sammanfattning : In gram negative sepsis, endotoxin from the bacterial membrane elicits proinflammatory and procoagulant host responses. Sepsis and its frequent complication disseminated intravascular coagulation (DIC) are leading causes of morbidity and mortality in the intensive care. LÄS MER