Sökning: "Multifocal tumors"

Visar resultat 1 - 5 av 9 avhandlingar innehållade orden Multifocal tumors.

  1. 1. Computational studies of mutational sequence signatures in cancer genomes

    Författare :Markus Lindberg; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; Genomcis; Mutational signatures; Ultraviolet light; Multifocal tumors;

    Sammanfattning : Cancer typically forms when mutational processes modify key cancer driver genes, resulting in positive selection and tumor growth. As such, mutational processes are at the core of the disease. Trinucleotide mutational signatures have emerged in the last decade as essential tools for analysis of mutational processes. LÄS MER

  3. 2. Studies on human polyomavirus infection in immunosuppressed patients with polyoma related tumors

    Författare :Peter Priftakis; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Polyomaviruses are potentially oncogenic viruses, found in humans, in other mammals and in birds all over the world. The polyomaviruses that have been observed in humans are BK virus (BKV) and JC virus (JCV) as well as the primate polyomavirus Simian Virus 40 (SV40). LÄS MER

  4. 3. Identification and characterization of candidate genes for neuroblastoma development

    Författare :Cecilia Krona; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cancer; tumor; child; embryonal; neural crest; neuroblastoma; chromosome 1; 1p36; mutation; expression; tumor suppressor gene; UBE4B; KIF1B; PGD; CORT; DFFA; PEX14; ICAT; CASP9; ENO1; MBP1; APITD1; PHOX2B;

    Sammanfattning : Neuroblastoma (NB) is the most common tumor during infancy. It arises from undifferentiated cells in the sympathetic nervous system and is characterized by both clinical and genetic heterogeneity. One of the features of NBs with unfavorable outcome is loss on distal chromosome 1p. LÄS MER

  5. 4. Breast cancer : Multifocality, heterogeneity, and related genetic signatures

    Författare :Gyula Pekar; Dumanski Jan; Sapino Anna; Uppsala universitet; []
    Nyckelord :breast; breast cancer multifocality; molecular phenotypes; intertumoral heterogeneity; biobanking; gene copy number aberrations;

    Sammanfattning : Breast carcinoma often exhibits a complex subgross morphology and may occupy a large volume of the breast tissue and show unifocal, multifocal or diffuse growth patterns. Expression of estrogen- and progesterone receptors, HER2 overexpression, tumor grade, and proliferative activity allows us to classify breast carcinoma into molecular subgroups (Luminal A, Luminal B, HER2-type, triple negative, and basal-like). LÄS MER

  7. 5. TINT Tumor Indicating Normal Tissue : new field of diagnostic biomarkers for prostate cancer

    Författare :Hanibal Hani Adamo; Anders Bergh; Göran Landberg; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; prostate cancer; biomarkers; TINT; patologi; Pathology;

    Sammanfattning : Background: Prostate cancer is the most common cancer in Sweden. Due its highly variable behavior, multifocal nature, and insufficient diagnostic methods, prostate cancer is difficult to diagnose and prognosticate. LÄS MER