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Visar resultat 21 - 25 av 321 avhandlingar som matchar ovanstående sökkriterier.

1. 21. Mechanisms and Biological Costs of Bacterial Resistance to Antimicrobial Peptides

   Författare :Hava Lofton Tomenius; Dan I Andersson; Ørjan Samuelsen; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antimicrobial peptides; antibiotic resistance; fitness cost; Salmonella Typhimurium; Staphylococcus aureus; bile; serum; pH response; growth rate; mice; phoP; pmrB; waaY; LPS; LL-37; defensins; membrane potential; Mikrobiologi; Microbiology;

   Sammanfattning : The global increasing problem of antibiotic resistance necessarily drives the pursuit and discovery of new antimicrobial agents. Antimicrobial peptides (AMPs) initially seemed like promising new drug candidates. Already members of the innate immune system, it was assumed that they would be bioactive and non-toxic. LÄS MER

3. 22. Antibiotic-induced Bacterial Toxin Release – Inhibition by Protein Synthesis Inhibitors

   Författare :Gunilla Hjerdt-Goscinski; Jan Sjölin; Monica Lundholm; Inga Odenholt; Ingrid Nilsson-Ehle; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Communicable diseases; Endotoxin; LPS; exotoxin; SpeA; penicillin-binding protein; aminoglycosides; clindamycin; β-lactam antibiotics; severe sepsis; septic shock; Infektionssjukdomar; Infectious diseases; Infektionssjukdomar;

   Sammanfattning : Toxic products, such as endotoxin from the gram-negative and exotoxin from the gram-positive bacteria, are the most important initiators of the inflammatory host response in sepsis. In addition to antibacterial treatment, numerous attempts have been made to interfere with the exaggerated proinflammatory cascade initiated by the toxins. LÄS MER

4. 23. Acute lung injury : study of pathogenesis and therapeutic interventions

   Författare :David Rocksén; Anders Bucht; Thomas Sandström; Johan Grunewald; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; ALI; ARDS; Dexamethasone; N-acetylcysteine; Vitamin E; LPS; Endotoxin; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin; lungmedicin; Lung Medicine;

   Sammanfattning : .... LÄS MER

5. 24. Endotoxin-induced inflammation in healthy human airways

   Författare :Margaretha E. Smith; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LPS; neutrophils; bronchoalveolar lavage; human airways; innate immunity;

   Sammanfattning : The aim of this thesis was to investigate the innate immune response in healthy human airways in vivo after simulation of a Gram-negative infection. Intrabronchial exposure to the TLR4 agonist endotoxin was used as a model for the innate mechanisms in the immune response that are caused by cigarette smoke and by natural infection with Gram-negative bacteria. LÄS MER

7. 25. Structure and lipid interactions of membrane-associated glycosyltransferases : Cationic patches and anionic lipids regulate biomembrane binding of both GT-A and GT-B enzymes

   Författare :Scarlett Szpryngiel; Lena Mäler; Marcelo Guerins; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; glycosyltransferase; monotopic membrane proteins; galactolipids; NMR; chitin synthase; DGD2; LPS; WaaG; MIT domain; Biophysics; biofysik;

   Sammanfattning : This thesis concerns work on structure and membrane interactions of enzymes involved in lipid synthesis, biomembrane and cell wall regulation and cell defense processes. These proteins, known as glycosyltransferases (GTs), are involved in the transfer of sugar moieties from nucleotide sugars to lipids or chitin polymers. LÄS MER