Sökning: "β-lactam antibiotics"

Visar resultat 1 - 5 av 22 avhandlingar innehållade orden β-lactam antibiotics.

  1. 1. Neurotoxicity of β-lactam antibiotics : experimental kinetic and neurophysiological studies

    Författare :Silvia E. Schliamser; Ragnar Norrby; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; benzylpenicillin; blood-brain barrier; ß-lactam antibiotics; CSF; CNS; EEG; imipenem cilastatin; FCE 22101; meningitis; neurotoxicity of; silent-second; thiopental; transport system; uraemia;

    Sammanfattning : The neurotoxic potential of intravenous administered benzylpenicillin (BPC) was studied in rabbits with intact blood-CNS barriers and rabbits with experimental E. coli meningitis. At onset of epileptogenic EEG activity or seizures, serum, CSF and brain tissue were collected for assay of BPC. LÄS MER

  3. 2. Antibacterial Effect and Inflammatory Response in Relation to Antibiotic Treatment of Sepsis

    Författare :Paul Skorup; Jan Sjölin; Miklós Lipcsey; Kristoffer Strålin; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Sepsis; Septic shock; Antibiotics; Aminoglycoside; β-lactam; Bacteria; E. coli; Inflammation; Cytokines; Endotoxin; Porcine; ICU; Secondary sepsis; Endotoxin-tolerance.; Infektionssjukdomar; Infectious Diseases;

    Sammanfattning : Sepsis defines as life-threatening organ dysfunction caused by a dysregulated host response to infection. The importance of early administration of antibiotics in septic shock is undisputed, but the optimal antibiotic choice remains uncertain. LÄS MER

  4. 3. Prognostic assessment in community acquired pneumonia

    Författare :Richard Dwyer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :β-lactam;

    Sammanfattning : Community acquired pneumonia (CAP) is the most commonly occurring infectious disease that requires hospital admission. CAP affects mainly, the youngest, the oldest, the poorest and the sickest. Annual incidence is 5-12 per 1000 adults. Between 20% and 40% of patients with CAP need in-hospital treatment. LÄS MER

  5. 4. Individualized treatment and control of bacterial infections

    Författare :Hanna Woksepp; Thomas Schön; Anders Johansson; Linnéuniversitetet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; therapeutic drug monitoring; intensive care unit; β-lactam antibiotics; antimicrobial drug resistance; molecular typing; whole-genome sequencing; Biomedical Sciences; Biomedicinsk vetenskap;

    Sammanfattning : Infectious diseases cause substantial morbidity and mortality, exacerbated by increasing antibiotic resistance. In critically ill patients, recent studies indicate a substantial variability in β-lactam antibiotic levels when standardized dosing is applied. LÄS MER

  7. 5. Antibiotic-induced Bacterial Toxin Release – Inhibition by Protein Synthesis Inhibitors

    Författare :Gunilla Hjerdt-Goscinski; Jan Sjölin; Monica Lundholm; Inga Odenholt; Ingrid Nilsson-Ehle; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Communicable diseases; Endotoxin; LPS; exotoxin; SpeA; penicillin-binding protein; aminoglycosides; clindamycin; β-lactam antibiotics; severe sepsis; septic shock; Infektionssjukdomar; Infectious diseases; Infektionssjukdomar;

    Sammanfattning : Toxic products, such as endotoxin from the gram-negative and exotoxin from the gram-positive bacteria, are the most important initiators of the inflammatory host response in sepsis. In addition to antibacterial treatment, numerous attempts have been made to interfere with the exaggerated proinflammatory cascade initiated by the toxins. LÄS MER