Sökning: "Hematology"

Visar resultat 36 - 40 av 150 avhandlingar innehållade ordet Hematology.

  1. 36. Exploring the heterogeneity of the hematopoietic stem and progenitor cell pool in cord blood

    Författare :Sofia Frändberg; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cord blood; Cord blood bank; Cord clamping; Hematopoietic stem cell transplantation; Hematopoietic stem and progenitor cells; CD34; Side Population; Aldehyde dehydrogenase; Apoptosis; CDCP1;

    Sammanfattning : Hematopoietic stem cell transplantation (HSCT) is a curative treatment for a wide range of malignant and hereditary disorders. It is yet the only clinically established stem cell treatment. LÄS MER

  3. 37. Identification of intrinsic regulators in normal and malignant human hematopoiesis. An RNA-interference approach

    Författare :Roman Galeev; Avdelningen för molekylärmedicin och genterapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hematopoietic stem cell; RNA interference; Acute myeloid leukemia; myelodysplastic syndrome; genetic screens; next generation sequencing; genetic regulators;

    Sammanfattning : Bildandet av blodceller, hematopoesen, utgår från ett litet antal av de så kallade hematopoetiska stamceller som sitter i vår benmärg. Dessa celler har förmågan att ge upphov till alla mogna blodcellstyper av de tre hematopoetiska linjerna, samtidigt som de genom celldelning bibehåller sin egna mängd. LÄS MER

  4. 38. A novel principle for immunomodulator delivery with hematopoietic cells as vehicles Focus on soluble TNF-receptor gene expression, targeting to secretory lysosomes and regulated secretion

    Författare :Ying Gao; Avdelningen för hematologi och transfusionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellulära vätskor; extracellular fluids; Hematologi; Medicin människa och djur ; Haematology; Medicine human and vertebrates ; neutrophil; granule; secretory lysosome; sorting; phagocytosis; degranulation.; mast cell; hematopoietic cell; inflammation; soluble TNF receptor;

    Sammanfattning : The goal of this research is to use hematopoietic cells as vehicles for targeting transgenic immunomodulators to the inflammatory sites. The work presented was focused on the anti-inflammatory soluble TNF receptor. A transmembrane soluble TNF receptor (sTNFR1) construct was expressed in hematopoietic cell lines. LÄS MER

  5. 39. Biosynthesis, Processing, and Sorting of Human Neutrophil Granule Proteins. Focus on Cathepsin G, Proteinase 3, and Azurocidin

    Författare :Daniel Garwicz; Avdelningen för hematologi och transfusionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematologi; extracellular fluids; Haematology; differentiation; bone marrow progenitor cells; preproform; mutations; Cell lines; transfection; extracellulära vätskor;

    Sammanfattning : The neutrophil granulocyte contains a number of multifunctional proteins stored in different subsets of granules. The azurophil granules, synthesized early during differentiation, harbour leukocyte elastase, cathepsin G, proteinase 3, and azurocidin; the members of the serprocidin family. LÄS MER

  7. 40. Methylome and Transcriptome Profiling of Hepatocytes Derived from Human Pluripotent Stem Cells

    Författare :Nidal Ghosheh; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human pluripotent stem cells; gene transcription; gene regulation; DNA methylation; transcriptome; hepatocytes;

    Sammanfattning : Six hundred million people suffering from liver diseases worldwide of which the lethality is two million. Freshly isolated hepatocytes from the liver have been used for transplantation purposes and are extensively used to recapitulate drug metabolism. LÄS MER