Sökning: "soluble TNF receptor"
Visar resultat 1 - 5 av 52 avhandlingar innehållade orden soluble TNF receptor.
1. Processing of TNF-receptors to soluble receptor forms in myeloid cells
Sammanfattning : TNF (Tumor Necrosis Factor) is a pro-inflammatory cytokine which binds to two cell surface receptors, TNF-R55 and TNF-R75. The receptors undergo proteolytic cleavage and release a fragment (soluble TNF-receptors or TNF-Binding Protein), TNF-R55-BP and TNF-R75-BP. Soluble TNF-receptors are able to bind and inactivate TNF. LÄS MER
2. A novel principle for immunomodulator delivery with hematopoietic cells as vehicles Focus on soluble TNF-receptor gene expression, targeting to secretory lysosomes and regulated secretion
Sammanfattning : The goal of this research is to use hematopoietic cells as vehicles for targeting transgenic immunomodulators to the inflammatory sites. The work presented was focused on the anti-inflammatory soluble TNF receptor. A transmembrane soluble TNF receptor (sTNFR1) construct was expressed in hematopoietic cell lines. LÄS MER
3. TNF-α and neurotrophins in Achilles tendinosis
Sammanfattning : Tenocytes are the principal cells of the human Achilles tendon. In tendinosis, changes in the metabolism and morphology of these cells occur. Neurotrophins are growth factors essential for the development of the nervous system. LÄS MER
4. Leukocyte receptor alternations during systemic inflammatory responses
Sammanfattning : The leukocyte adhesion molecule CD llb is very important when granulocytes and monocytes leave the blood stream. This adhesion molecule is stored preformed intracellularly, and can upon stimulation of the cells by, for example, complement split products, be mobilized to the cell surface. LÄS MER
5. Cytokines and their soluble receptors in nasal fluids from school children with allergic rhinitis
Sammanfattning : Allergic inflammation is associated with a shift in the balance between cytokines produced by two T helper subsets (Th1 and Th2) towards a preponderance of Th2 cells. Interleukin (IL)-4 is produced by Th2 cells and interferon-g (IFN-g) by Th1 cells. The ratio IL-4/IFN-g is often used as a marker of the balance between the cytokines. LÄS MER