Sökning: "HSP90 inhibition"
Visar resultat 1 - 5 av 8 avhandlingar innehållade orden HSP90 inhibition.
1. Oesophageal Cancer – Novel Targets for Therapy : With focus on Hsp90, EGFR, LRIG, microtubule and telomerase
Sammanfattning : Oesophageal cancer is a malignant and aggressive disease with very poor survival. The aim of this thesis was to evaluate novel therapeutic targets in oesophageal cancer. In paper I, Hsp90 was expressed in all 81 oesophageal cancer tissues and also in nine oesophageal cancer cell lines. LÄS MER
2. Searching for Synergy : Radiosensitization of 177Lu-DOTATATE
Sammanfattning : Cancers presents a major health challenge, and there is a pressing need to develop new therapeutic strategies. Surgery, chemotherapy and radiation are the most commonly used treatments for cancer today. Radiation can be given as targeted radionuclide therapy (TRT), i.e. LÄS MER
3. Functional analysis of the proteasome in eukaryotic organisms
Sammanfattning : Proteasome degradation machinery is responsible for the turnover of a huge variety of normal and abnormal proteins, thus regulating a plethora of cellular processes. Aging is an inevitable biological process that is characterized by reduced proteasome function that leads to proteotoxic stress. LÄS MER
4. Towards Personalized Cancer Therapy : New Diagnostic Biomarkers and Radiosensitization Strategies
Sammanfattning : This thesis focuses on the evaluation of biomarkers for radio-immunodiagnostics and radio-immunotherapy and on radiosensitization strategies after HSP90 inhibition, as a step towards more personalized cancer medicine. There is a need to develop new tracers that target cancer-specific biomarkers to improve diagnostic imaging, as well as to combine treatment strategies to potentiate synergistic effects. LÄS MER
5. Targeting glutathione peroxidases : identifying environmental modulators, and screening for novel small molecule inhibitors
Sammanfattning : Glutathione peroxidases (GPXs) are a family of selenoproteins that are critical regulators of reactive oxygen species (ROS) in the cell, specifically hydroperoxides like hydrogen peroxide (H2O2). ROS are important for normal cell signaling and are tightly controlled to promote cell growth, proliferation, and survival. LÄS MER