Sökning: "CD44v6"

Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet CD44v6.

  1. 1. Towards Personalized Cancer Therapy New Diagnostic Biomarkers and Radiosensitization Strategies

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Diana Spiegelberg; Uppsala universitet.; [2015]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tumor targeting; radionuclide targeting; HSP90 inhibition; AT13387; radiosensitization; molecular imaging; combination treatment; EGFR; CD44v6; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

    Sammanfattning : This thesis focuses on the evaluation of biomarkers for radio-immunodiagnostics and radio-immunotherapy and on radiosensitization strategies after HSP90 inhibition, as a step towards more personalized cancer medicine. There is a need to develop new tracers that target cancer-specific biomarkers to improve diagnostic imaging, as well as to combine treatment strategies to potentiate synergistic effects. LÄS MER

  2. 2. Precision medicine and targeted therapy Turning the tables on cancer

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Anja Mortensen; Uppsala universitet.; [2018]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; p53 cancers; PM2; radiosensitization; radio-immunotherapy; MDM2 X inhibition; combination therapy; targeted radionuclide therapy; CD44v6; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

    Sammanfattning : An extended understanding of the molecular characteristics of cancer has led to a revolution within the field of precision medicine. This thesis explores the utilization of two targets for precision medicine, namely, CD44v6 and murine double-minute 2 and X (MDM2/X). LÄS MER

  3. 3. Targeting molecules for diagnostics of Head and Neck squamous cell carcinoma

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Anna-Karin Haylock; Uppsala universitet.; [2017]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HNSCC; CD44v6; radio-immunodiagnosis; immuno-PET; tumor targeting; antibodies; antibody fragments; Oto-Rhino-Laryngology; Oto-rhino-laryngologi;

    Sammanfattning : To personalize treatment for cancer, correct staging of the primary tumor, nodal disease and metastatic disease is of essence. By targeting tumor specific receptors with radiolabeled antibodies, specificity and accuracy of imaging may be improved. LÄS MER

  4. 4. Diagnosis and Radioimmunotherapy of Head and Neck Squamous Cell Carcinomas

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Tomas Ekberg; Uppsala universitet.; [2008]
    Nyckelord :Otorhinolaryngology; head and neck squamous cell carcinoma; tumor targeting; radionuclide targeting; PET; therapy; diagnistics; antibodies; Otorhinolaryngologi;

    Sammanfattning : The diagnosis and treatment of patients with advanced tumors in the head and neck is an interesting challenge where there is a need for new approaches in diagnostics and adjuvant treatment. Differences in antigen expression between tumors and normal tissues provide a means for application of antibody-based targeting techniques. LÄS MER

  5. 5. Antibody-Based Radionuclide Targeting for Diagnostics and Therapy Preclinical Studies on Head and Neck Cancer

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Marika Nestor; Uppsala universitet.; [2006]
    Nyckelord :Otorhinolaryngology; antibodies; radionuclide targeting; tumour targeting; therapy; diagnostics; immuno-PET; head and neck squamous cell carcinoma; Otorhinolaryngologi;

    Sammanfattning : Antibody-based targeting techniques play an increasingly important role in cancer research. By targeting a structure that is abundant in tumour cells, but rare in healthy tissues, an antibody can mediate the delivery of radioactivity specifically to tumour cells in the body. LÄS MER