Sökning: "radiosensitisation"

Hittade 2 avhandlingar innehållade ordet radiosensitisation.

1. 1. Oesophageal Cancer – Novel Targets for Therapy : With focus on Hsp90, EGFR, LRIG, microtubule and telomerase

   Författare :Xuping Wu; Simon Ekman; Johan Lennartsson; Ylva Pausson-Karlsson; Michael Bergqvist; Joachim Gullbo; Stefan Bergstöm; Gunilla Enblad; Claes Mercke; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hsp90; EGFR; LRIG; microtubule; telomerase; oesophageal cancer; imetelstat; DNA double-strand break; 17-AAG; radiation; prognosis; radiosensitisation; microtubule targeting agents; Oncology; Onkologi; Oncology; Onkologi;

   Sammanfattning : Oesophageal cancer is a malignant and aggressive disease with very poor survival. The aim of this thesis was to evaluate novel therapeutic targets in oesophageal cancer. In paper I, Hsp90 was expressed in all 81 oesophageal cancer tissues and also in nine oesophageal cancer cell lines. LÄS MER

3. 2. The use of IGF-IR inhibitors in cancer therapy : a potential approach for sensitizing tumor cells to ionizing radiation

   Författare :Daria Cosaceanu; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : This study focused on insulin-like growth factor I receptor (IGF-IR), considered as a promising therapeutic target for cancer treatment. We were in particular interested in the involvement of IGF-IR in tumor cells response to radiation and we tried to provide the rationale for a combined therapy of IFG4R inhibitors with radiation in order to improve the therapeutic outcome. LÄS MER