Sökning: "HCV"

Visar resultat 6 - 10 av 95 avhandlingar innehållade ordet HCV.

1. 6. Design and Synthesis of Hepatitis C Virus NS3 Protease Inhibitors Incorporating a P2 Cyclopentane-Derived Scaffold

   Författare :Marcus Bäck; Anja Sandström; Linköpings universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; HCV; NS3 protease; Proline mimic; Cyclopentane-derived scaffold; Linear inhibitors; Macrocyclic inhibitors; Organic synthesis; Organisk syntes;

   Sammanfattning : This thesis describes the design, synthesis and structure-activity relationships analysis of potential inhibitors targeting the hepatitis C virus (HCV) NS3 protease. Also discussed is the disease caused by HCV infection and the class of enzymes known as proteases. LÄS MER

3. 7. Design and Synthesis of Inhibitors Targeting the Hepatitis C Virus NS3 Protease : Focus on C-Terminal Acyl Sulfonamides

   Författare :Robert Rönn; Anders Hallberg; Anja Sandström; Federico Corelli; Uppsala universitet; []
   Nyckelord :Pharmaceutical chemistry; hepatitis C virus; HCV; NS3 protease inhibitor; acyl sulfonamide; bioisostere; palladium; carbonylation; microwave; molybdenum hexacarbonyl; Farmaceutisk kemi;

   Sammanfattning : Hepatitis C is a global health problem that affects approximately 120–180 million people. This viral infection causes serious liver diseases and the therapy available suffers from low efficiency and severe side effects. Consequently, there is a huge unmet medical need for new therapeutic agents to combat the hepatitis C virus (HCV). LÄS MER

4. 8. Design and Synthesis of Serine and Aspartic Protease Inhibitors

   Författare :Fredrik Wångsell; Ingemar Kvarnström; Olle Karlsson; Linköpings universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; organic chemistry; organic synthesis; metathesis; HCV; NS3; protease; proline isosteres; inhibitor; aspartic protease inhibitors; hydroxyethylene; Organic synthesis; Organisk syntes;

   Sammanfattning : This thesis describes the design and synthesis of compounds that areintended to inhibit serine and aspartic proteases. The first part of the text deals with preparation of inhibitors of the hepatitis C virus (HCV) NS3 serine protease. Hepatitis C is predominantly a chronic disease that afflicts about 170 million people worldwide. LÄS MER

5. 9. Impact of Genetic Variants in Inosine Triphosphate Pyrophosphatase and Interferon-λ4 on Natural History, Treatment Response and Ribavirin Pharmacology in Hepatitis C Virus Infection

   Författare :Jesper Waldenström; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hepatitis C virus; HCV; Inosine triphosphate pyrophosphatase; ITPA; interferon-λ4; IFNL4; ribavirin; interferon; PWID; IP-10;

   Sammanfattning : Hepatitis C virus (HCV) impacts on global health with around 70 million chronically infected worldwide. The infection increases the risk of cirrhosis and primary liver cancer. The treatment until 2013 has been based on interferon-α and ribavirin, but is now replaced by direct acting antivirals. LÄS MER

7. 10. Characterization of HCV Protease Inhibitors : Inhibition and Interaction Studies with Applications for Drug Discovery

   Författare :Sofia Svahn Gustafsson; U. Helena Danielson; Johan Neyts; Uppsala universitet; []
   Nyckelord :Biokemi; Biochemistry;

   Sammanfattning : In this thesis, different approaches based on inhibition and interactions studies, have been used to characterize inhibitors of the non-structural protein 3 (NS3) from the hepatitis C virus (HCV). This involves identification of enzyme inhibitory effects and characterization of interaction mechanisms and kinetics, as well as effects on replication in a cell based system and serum protein binding. LÄS MER