Sökning: "IP-10"

Visar resultat 1 - 5 av 33 avhandlingar innehållade ordet IP-10.

  1. 1. Immunological and Genetic Markers Predicting Treatment Outcome in Hepatitits C Virus Infection

    Författare :Galia Askarieh; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IP-10; CXCL10; CD26; hepatitis C virus; interferon; ribavirin; treatment; IL28B;

    Sammanfattning : Hepatitis C is a blood-borne infection caused by the hepatitis C virus (HCV). A chronic infection, which develops in most infected subjects, may lead to liver cirrhosis with ensuing liver dysfunction and liver cancer. LÄS MER

  3. 2. Impact of Genetic Variants in Inosine Triphosphate Pyrophosphatase and Interferon-λ4 on Natural History, Treatment Response and Ribavirin Pharmacology in Hepatitis C Virus Infection

    Författare :Jesper Waldenström; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hepatitis C virus; HCV; Inosine triphosphate pyrophosphatase; ITPA; interferon-λ4; IFNL4; ribavirin; interferon; PWID; IP-10;

    Sammanfattning : Hepatitis C virus (HCV) impacts on global health with around 70 million chronically infected worldwide. The infection increases the risk of cirrhosis and primary liver cancer. The treatment until 2013 has been based on interferon-α and ribavirin, but is now replaced by direct acting antivirals. LÄS MER

  4. 3. On the outcome of antiviral therapy for hepatitis C virus genotype 2 or 3 infection

    Författare :Åsa Alsiö; Göteborgs universitet; []
    Nyckelord :infectious diseases; virology; hepatitis c; treatment;

    Sammanfattning : Abstract Approximately 80% of patients infected with HCV genotypes 2 or 3 achieve a sustained virological response (SVR), following 24 weeks of therapy with ribavirin and pegylated interferon (peg-IFN), but in light of considerable side effects and cost, shortened treatment duration without impaired efficacy is desirable. Thus, 382 genotype 2/3 infected patients were randomized in an investigator-initiated phase III study (NORDynamIC) evaluating the efficacy of 12 (short-term) vs. LÄS MER

  5. 4. Immunological aspects of latent tuberculosis infection during pregnancy

    Författare :Fregenet Tesfaye Tegegn; Klinisk infektionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Interferon-γ; immune mediators; latent tuberculosis infection; Mtb-antigen reactivity; pregnancy; QuantiFERON-TB Gold Plus;

    Sammanfattning : Pregnancy-induced immune modulation might lead to reactivation of latent tuberculosis infection (LTBI). This thesis explores aspects of immune-based LTBI diagnostics and how pregnancy affects the immune control of Mycobacterium tuberculosis (Mtb) infection. We studied a prospective cohort of women recruited during pregnancy in Ethiopia. LÄS MER

  7. 5. Immunological mechanisms in systemic autoimmunity : autoantibodies and chemokines in systemic lupus erythematosus and during treatment with TNF inhibitors in rheumatoid arthritis

    Författare :Catharina Eriksson; Karl-Gösta Sundqvist; Solbritt Rantapää-Dahlqvist; Mari Norgren; Thomas Skogh; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; autoimmunity; chemokines; T-cells; autoantibodies; CD91; Clinical immunology; Klinisk immunologi; Rheumatology; Reumatologi; Clinical Immunology; klinisk immunologi; reumatologi; rheumatology;

    Sammanfattning : Background. Rheumatoid Arthritis (RA) is an autoimmune inflammatory disease that, without powerful treatment, may lead to irreversible joint damage. During the past decade, anti-cytokine therapy has become available, e.g. LÄS MER