Sökning: "Sofia Svahn Gustafsson"

Hittade 1 avhandling innehållade orden Sofia Svahn Gustafsson.

1. 1. Characterization of HCV Protease Inhibitors : Inhibition and Interaction Studies with Applications for Drug Discovery

   Författare :Sofia Svahn Gustafsson; U. Helena Danielson; Johan Neyts; Uppsala universitet; []
   Nyckelord :Biokemi; Biochemistry;

   Sammanfattning : In this thesis, different approaches based on inhibition and interactions studies, have been used to characterize inhibitors of the non-structural protein 3 (NS3) from the hepatitis C virus (HCV). This involves identification of enzyme inhibitory effects and characterization of interaction mechanisms and kinetics, as well as effects on replication in a cell based system and serum protein binding. LÄS MER