Sökning: "HCV"

Visar resultat 26 - 30 av 95 avhandlingar innehållade ordet HCV.

  1. 26. Computational Studies of Macrocycles and Molecular Modeling of Hepatitis C Virus NS3 Protease Inhibitors

    Författare :Hiba Alogheli; Anders Karlén; Anja Sandström; Peter Brandt; Leif Eriksson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Drug discovery; HCV NS3 protease; macrocycles; conformational analysis; docking.; Medicinal Chemistry; Läkemedelskemi;

    Sammanfattning : Computational tools are utilized in the drug discovery process to discover, design, and optimize new therapeutics. One important approach is structure-based drug design which relies on knowledge about the 3D structure of the biological target. LÄS MER

  3. 27. Development of a therapeutic vaccine against the hepatitis C virus

    Författare :Gustaf Ahlén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HCV; NS3; DNA vaccine; electroporation;

    Sammanfattning : The hepatitis C virus (HCV) infection is a major cause of liver disease and it is estimated that 170 million people worldwide are chronically infected by HCV. There are no protective or curable vaccines available for HCV, however treatment consisting of interferon-α and ribavirin is curative in 45-75% of the chronic infected patients, depending on the viral genotype. LÄS MER

  4. 28. Molecular epidemiology of hepatitis A, B and C in Estonia

    Författare :Tatjana Tallo; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HAV; HBV; HCV; strains; genotype; phylogenetic analysis;

    Sammanfattning : During the last decade changes have occurred in the epidemiology of hepatitis A, B and C in Estonia. A shift from high to intermediate endemicity for HAV has led to a shift in age of susceptible individuals from children to adolescents and adults. LÄS MER

  5. 29. Molecular epidemiology of hepatitis A, B and C in Estonia

    Författare :Tatjana Tallo; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HAV; HBV; HCV; strains; genotype; phylogenetic analysis;

    Sammanfattning : During the last decade changes have occurred in the epidemiology of hepatitis A, B and C in Estonia. A shift from high to intermediate endemicity for hepatitis A has led to a shift in age of susceptible individuals from children to adolescents and adults. LÄS MER

  7. 30. Nucleic acid-based detection and characterization of hepatitis C virus

    Författare :Zhibing Yun; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HCV; PCR; genotype; HVRI; heterogeneity; IFN-a; immunodeficiency;

    Sammanfattning : Nucleic acid-based methods were developed to detect and characterize the HCV genome in immunocompetent and immunodeficient patents of whom some were IFN-a treated. HCV RNA was found in most sera (95%), livers (97%) and PBMC (100%) of patients with confirmed chronic hepatitis, but also in sera (21%) of patients with indeterminate confirmatory antibody test, especially those with c22 antigen reactivity. LÄS MER