Sökning: "H2AX"

Visar resultat 1 - 5 av 23 avhandlingar innehållade ordet H2AX.

  1. 1. DNA damage affecting thyroidal iodide transport: an explanation to thyroid stunning

    Författare :Madeleine Nordén; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :thyroid; radioiodide; thyroid stunning; NIS; cell cycle; genotoxic stress; DNA damage; H2AX; ATM;

    Sammanfattning : 131I is widely used clinically in the treatment of Graves´ disease and differentiated thyroid cancer. However, cellular and molecular effects of 131I irradiation in relation to absorbed dose are poorly documented. LÄS MER

  2. 2. In vitro radiobiological effects of 131I on thyroid cells: towards a mechanistic understanding of thyroid stunning

    Författare :Nirmal Bhogal; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :thyroid; radioiodide; stunning; 131I; stress response; DNA damage; Chk2; H2AX; micronuclei; cell cycle;

    Sammanfattning : .... LÄS MER

  3. 3. Measurements of the DNA double-strand break response

    Författare :Aida Muslimovic; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :DSB response; cancer patients; H2AX phosphorylation;

    Sammanfattning : Radiotherapy and some chemotherapeutic drugs kill cancer cells by induction of the extremely toxic DNA double-strand breaks (DSBs). Measurements of the DSB response in patients during therapy could allow personalized dosing to improve tumor response and minimize side effects. LÄS MER

  4. 4. Quantification of Radiation Induced DNA Damage Response in Normal Skin Exposed in Clinical Settings

    Författare :Martin Simonsson; Ingela Turesson; Gunilla Enblad; Dag Rune Olsen; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA damage response; low-dose hypersensitivity; dose response; normal tissue; epidermis; dermis; keratinocyte; fractionated radiotherapy; DNA double strand break; DSB; foci; gamma-H2AX; 53BP1; p21; checkpoint; apoptosis; mitosis; micro-RNA; miR-34a; Oncology; Onkologi; Oncology; Onkologi;

    Sammanfattning : The structure, function and accessibility of epidermal skin provide aunique opportunity to study the DNA damage response (DDR) of a normaltissue. The in vivo response can be examined in detail, at a molecularlevel, and further associated to the structural changes, observed at atissue level. LÄS MER

  5. 5. Recognition and signaling of DNA double-strand breaks in human cells

    Författare :Ismail Hassan Ismail; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :DNA-PK; DNA double-strand break; DSB; DNA single-strand break; SSB; DNA damage; ionizing radiation; IR; DNA repair; calicheamicin kappa1; ATM; hydrogen peroxide; H2AX; radiotherapy; radiosensitizer; flow cytometry;

    Sammanfattning : DNA double-strand breaks (DSBs) are the most toxic type of DNA damage. Fortunately, our cells have highly conserved pathways that detect and repair DSBs. Defects in DSB signaling and DSB repair pathways result in genomic instability that predisposes for cancer development. LÄS MER