Sökning: "H2AX phosphorylation"

Visar resultat 1 - 5 av 12 avhandlingar innehållade orden H2AX phosphorylation.

  1. 1. Measurements of the DNA double-strand break response

    Författare :Aida Muslimovic; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DSB response; cancer patients; H2AX phosphorylation;

    Sammanfattning : Radiotherapy and some chemotherapeutic drugs kill cancer cells by induction of the extremely toxic DNA double-strand breaks (DSBs). Measurements of the DSB response in patients during therapy could allow personalized dosing to improve tumor response and minimize side effects. LÄS MER

  3. 2. Recognition and signaling of DNA double-strand breaks in human cells

    Författare :Ismail Hassan Ismail; Göteborgs universitet; []
    Nyckelord :DNA-PK; DNA double-strand break; DSB; DNA single-strand break; SSB; DNA damage; ionizing radiation; IR; DNA repair; calicheamicin kappa1; ATM; hydrogen peroxide; H2AX; radiotherapy; radiosensitizer; flow cytometry;

    Sammanfattning : DNA double-strand breaks (DSBs) are the most toxic type of DNA damage. Fortunately, our cells have highly conserved pathways that detect and repair DSBs. Defects in DSB signaling and DSB repair pathways result in genomic instability that predisposes for cancer development. LÄS MER

  4. 3. Induction and repair of DNA double-strand breaks in human cells exposed to different radiation qualities

    Författare :Irina Radulescu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :DSB; chromatin structure; high-LET; heat-labile sites; PFGE; DNA-PKcs; XRCC1; PARP-1; pATM; gamma-H2AX; 53BP1;

    Sammanfattning : Radiation therapy is used in attempting to kill tumor cells by inducing DNA double- strand breaks (DSB), the most critical DNA lesions. Recent and planned radiation therapy strategies use high-linear energy transfer (LET) radiation to effectively treat malignant tumors. LÄS MER

  5. 4. Polycyclic aromatic hydrocarbons : DNA damage and cell signaling

    Författare :Åse Mattsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Oxidative stress is a threat to our wellbeing. The formation of reactive oxygen species may result in oxidative lesions in DNA and RNA. When challenging A549 cells with 18O-labeled hydrogen peroxide, we found that RNA was between 14-25 times more sensitive to [18O]-8-oxoGuo formation than [18O]-8-oxodGuo formation in DNA. LÄS MER

  7. 5. The exosome and the maintenance of genome integrity

    Författare :Judit Domingo Prim; Neus Visa; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : The RNA exosome acts on different RNA substrates and plays important roles in RNA metabolism. The fact that short non-coding RNAs are involved in the DNA damage response led us to investigate whether the exosome plays a role in DNA repair. LÄS MER