Sökning: "miR-34a"
Visar resultat 1 - 5 av 9 avhandlingar innehållade ordet miR-34a.
1. Quantification of Radiation Induced DNA Damage Response in Normal Skin Exposed in Clinical Settings
Sammanfattning : The structure, function and accessibility of epidermal skin provide aunique opportunity to study the DNA damage response (DDR) of a normaltissue. The in vivo response can be examined in detail, at a molecularlevel, and further associated to the structural changes, observed at atissue level. LÄS MER
2. Conformational dynamics in microRNAs : the example of miR-34a targeting Sirt1 mRNA
Sammanfattning : In biology, regulatory mechanisms are essential to achieve complex tasks, as virtually every process can be positively or negatively modulated in its outcome, upon different cues. In humans, microRNAs (miRNAs) constitute a fundamental layer of post-transcriptional gene expression regulation. LÄS MER
3. Axl RTK and microRNAs in urogenital cancers
Sammanfattning : This thesis is based on four projects focused on the Axl receptor tyrosine kinase (RTK) and microRNAs in clear cell renal cell carcinoma (ccRCC) and in prostate cancer (PCa). Paper I focuses on differentially expressed microRNAs in ccRCC. LÄS MER
4. Dissecting the role of micro-RNAs in diabetes
Sammanfattning : The role of miRNAs in pancreatic islets and β-cell function and in the development of diabetes in human and rodents have been investigated in this thesis. Dicer1 was specifically deleted in vivo in pancreatic β-cells under the RIP-promoter in mice. LÄS MER
5. A multifactorial approach to targeting signalling pathways in diabetic foot ulcers
Sammanfattning : Diabetic foot ulcers (DFU) are one of the most debilitating complication of diabetes that adversely impacts the health, economics and quality of life of the afflicted individual. The primary pathogenic factor of DFU is hyperglycemia, and its negative effects on normal signaling pathways is still being investigated. LÄS MER