Sökning: "low-dose hypersensitivity"

Hittade 5 avhandlingar innehållade orden low-dose hypersensitivity.

  1. 1. DNA Damage Response of Normal Epidermis in the Clinical Setting of Fractionated Radiotherapy : Evidence of a preserved low-dose hypersensitivity response

    Författare :Fredrik Qvarnström; Ingela Turesson; Gunilla Enblad; Mats Harms-Ringdahl; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA damage response; low-dose hypersensitivity; dose response; normal tissue; epidermis; keratinocyte; fractionated radiotherapy; DNA double strand break; DSB; foci; γH2AX; 53BP1; checkpoint; p21; apoptosis; mitosis; Oncology; Onkologi; Oncology; onkologi;

    Sammanfattning : Investigations of DNA damage response (DDR) mechanisms in normal tissues have implications for both cancer prevention and treatments. The accumulating knowledge about protein function and molecular markers makes it possible to directly trace and interpret cellular DDR in a tissue context. LÄS MER

  3. 2. Quantification of Radiation Induced DNA Damage Response in Normal Skin Exposed in Clinical Settings

    Författare :Martin Simonsson; Ingela Turesson; Gunilla Enblad; Dag Rune Olsen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA damage response; low-dose hypersensitivity; dose response; normal tissue; epidermis; dermis; keratinocyte; fractionated radiotherapy; DNA double strand break; DSB; foci; gamma-H2AX; 53BP1; p21; checkpoint; apoptosis; mitosis; micro-RNA; miR-34a; Oncology; Onkologi; Oncology; Onkologi;

    Sammanfattning : The structure, function and accessibility of epidermal skin provide aunique opportunity to study the DNA damage response (DDR) of a normaltissue. The in vivo response can be examined in detail, at a molecularlevel, and further associated to the structural changes, observed at atissue level. LÄS MER

  4. 3. How to reduce the exposure to anticoagulants when performing haemodialysis in patients with a bleeding risk : a study of methods used in clinical practise

    Författare :Malin Skagerlind; Bernd Stegmayr; Birgitta Olofsson; Fredrik Uhlin; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute kidney injury; dialysis; hemorrhage; anticoagulation; Akut njursvikt; dialys; blödning; antikoagulation; medicin; Medicine;

    Sammanfattning : When a patient suffers from kidney failure and also has an enhanced risk of bleeding, the standard haemodialysis (HD) treatment becomes a problem. When human blood comes in contact with artificial material, as in the tubing system and in the dialyser (the extra corporeal circuit, ECC), the coagulation system is activated. LÄS MER

  5. 4. Angina pectoris : neurophysiological mechanisms with special references to adenosine and Syndrome X

    Författare :Björn E Eriksson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Angina pectoris; adenosine; myocardial ischemia; nociception; cardiac nervous system; neuropathic; analgesia; [beta]-endorphin; met-enkephlin; exercise; Syndrome X; silent ischemia; biopsies; physical training;

    Sammanfattning : Angina pectoris is the major symptom of ischemic heart disease (IHD). It is a visceral pain and the clinical presentation is complex. Its character is not well defined and this is reflected in a lack of specific pain-mediating neural structures. LÄS MER

  7. 5. Nerve injury induced pain and spinal cord stimulation

    Författare :Camilla Ultenius; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Neuropathic pain;

    Sammanfattning : Chronic neuropathic pain caused by injury to or disease in the nervous system is relatively common and results in major suffering, poor quality of life and incapacity. Such pain is a therapeutic challenge because a considerable portion of the patients fails to benefit from pharmacotherapy. LÄS MER