Sökning: "H2AX"

Visar resultat 16 - 20 av 25 avhandlingar innehållade ordet H2AX.

  1. 16. 5-Fluorouracil mediated cell death signaling
 in colon carcinoma cells

    Författare :Birce Akpinar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Colorectal cancer (CRC) is the third most common form of cancer in the world. 5- Fluorouracil (5-FU) belongs to the fluoropyrimidine-type of drugs and is commonly used in the treatment of several solid tumors. It has become the mainstay of CRC treatment at stage III and high risk stage II, either alone or in combination with other drugs. LÄS MER

  3. 17. Cellular responses to the DNA damaging cytolethal distending toxin

    Författare :Lina Guerra; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cytolethal distending toxin (CDT) is a genotoxin, which belongs to a group of bacterial protein toxins called cyclomodulins. These are characterized by their interference with the eukaryotic cell cycle. CDT causes DNA damage, which induces cell cycle arrest and apoptosis. LÄS MER

  4. 18. Dendritic cells in the development of antimicrobial immunity : studies on Epstein-Barr virus and the Haemophilus ducreyi cytolethal distending toxin

    Författare :LiQi Li; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Dendritic cells; Epstein-Barr virus; Haemophilus ducreyi cytolethal distending toxin; immune escape;

    Sammanfattning : Dendritic cell (DC) plays a pivotal role in both innate and adaptive immunity, we studied the inhibitory effect of pathogens on the development and maturation of monocyte derived DCs, with special emphasis on the effect of Epstein-Barr virus (EBV) and Haemophilus ducreyi cytolethal distending toxin (HdCDT). Results demonstrate that EBV infection of monocytes inhibits their development into dendritic cells by interfering their responsiveness to granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin (IL)-4. LÄS MER

  5. 19. Polycyclic aromatic hydrocarbons : DNA damage and cell signaling

    Författare :Åse Mattsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Oxidative stress is a threat to our wellbeing. The formation of reactive oxygen species may result in oxidative lesions in DNA and RNA. When challenging A549 cells with 18O-labeled hydrogen peroxide, we found that RNA was between 14-25 times more sensitive to [18O]-8-oxoGuo formation than [18O]-8-oxodGuo formation in DNA. LÄS MER

  7. 20. Genotoxic stress : novel biomarkers and detection methods : uncovering RNAs role in epigenetics of carcinogenesis

    Författare :Edyta Zofia Bajak; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Cancer is a complex disease that is caused by the interplay of multiple genes and diverse environmental factors. As such, there has been continual debate as to which component of this complicated process towards development of neoplasia plays the most important role. LÄS MER