Sökning: "H2AX"
Visar resultat 21 - 25 av 25 avhandlingar innehållade ordet H2AX.
21. Small-Scale Dosimetry for the Testis: Applications in Nuclear Medicine Diagnostics and Therapy
Sammanfattning : It is well known that the testicles are among the most radiosensitive tissue, and constitute an important critical target for both external and internal radiation during diagnostic and therapeutic use of radionuclides. In systemic radionuclide therapy where very high activities are administered, the testis may become a dose-limiting organ; often with a complex, non-uniform activity distribution and a resulting non-uniform absorbed-dose distribution. LÄS MER
22. Dihydroorotate dehydrogenase : new insights into an old target
Sammanfattning : Purine and pyrimidine nucleotides are important for both biosynthetic and regulatory pathways in cells. As constituents of the DNA and RNA molecules, the requirements for nucleotides in actively dividing cells are increased. LÄS MER
23. Study of the mechanisms behind the additive effect of neoadjuvant castration on radiotherapy for prostate cancer
Sammanfattning : Castration improves responses to radiotherapy (RT) in prostate cancer with unknown mechanism. An understanding of what happens at the cellular and molecular level in prostate cancer cells, while reducing their access to androgens and then exposing them to ionizing radiation (IR), would give us an opportunity to optimize the treatment and may also inspire novel therapeutic approaches. LÄS MER
24. DNA fragility in the context of neural stem cell fate : a multi-method integrative exploration of genome dynamics
Sammanfattning : Recent advances in mapping the complex genetic architecture underlying various debilitating brain disorders have enabled identification of several genetic risk variants. However, these risk variants only explain part of the heritability and vulnerability to these disorders in early development. LÄS MER
25. Identification and characterization of small molecules targeting MYC function
Sammanfattning : The MYC family genes (c-, N- and L-MYC) encode potent oncoproteins/transcription factors regulating fundamental cellular processes involved in cell proliferation, metabolism and survival, and they play an important role in tumor development. Overexpression of MYC often induce apoptosis as a failsafe mechanism to prevent tumor development and it is known to sensitize cells to genotoxic agents that induce DNA damage by triggered apoptosis. LÄS MER