Sökning: "Gamma-aminobutyric acid"

Visar resultat 6 - 10 av 18 avhandlingar innehållade orden Gamma-aminobutyric acid.

1. 6. The optic tectum of the salmon:site of interaction of neurohormonal photoperiodic and neural visual signals. The GABAergic neuronal system and melatonin receptors

   Författare :Marie Anzelius; Biologiska institutionen; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Animal anatomy; melatonin receptors; GABA; optic tectum; fish; brain; animal morphology; Djurs anatomi och morfologi;

   Sammanfattning : Melatonin is a neurohormone which mediates photoperiodic signals from the pineal organ to the brain. GABA (g-aminobutyric acid) is the major inhibitory transmitter in the central nervous system. LÄS MER

3. 7. Physiology and Pharmacology of GABAA receptors: The Brakes in the Brain

   Författare :Catarina Lindquist; Malmö Institutionen för kliniska vetenskaper; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology; Fysiologi; Ion channels; GABA; Inhibition;

   Sammanfattning : Inhibitory neurotransmission in the brain is mostly mediated by gamma-aminobutyric acid type A (GABAA) receptors. These receptors are involved in both phasic inhibition (point-to-point inhibition, synaptic transmission) and tonic inhibition (diffuse form of inhibition, brain homeostasis). LÄS MER

4. 8. Simulating Functional Cycles and Drug Modulation in Ligand-gated Ion Channels

   Författare :Yuxuan Zhuang; Erik Lindahl; Grace Brannigan; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ion channels; molecular dynamics; markov state model; lipid modulation; nicotinic receptor; protein conformational transitions; Biophysics; biofysik;

   Sammanfattning : Understanding the intricate motions and conformational changes that govern biological processes remains a fascinating and challenging endeavor. The research presented in this thesis aims to elucidate the dynamic processes underlying biological functions, specifically focusing on the dynamics of pentameric ligand-gated ion channels (pLGICs), which play a crucial role in signal transduction within the brain. LÄS MER

5. 9. Chemical signalling in the Drosophila brain : GABA, short neuropeptide F and their receptors

   Författare :Lina E. Enell; Dick Nässel; Jonathan Bacon; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Insect nervous system; Drosophila; GABA; sNPF; GPCR; ion channel receptor; feeding; metabolic stress; olfaction; antennal; lobe; mushroom body; Morphology; Morfologi; funktionell morfologi; Functional Zoomorphology;

   Sammanfattning : Gamma-aminobutyric acid (GABA) and short neuropeptide F (sNPF) are widespread signalling molecules in the brain of insects. In order to understand more about the signalling and to some extent start to unravel the functional roles of these two substances, this study has examined the locations of the transmitters and their receptors in the brain of the fruit fly Drosophila melanogaster using immunocytochemistry in combination with Gal4/UAS technique. LÄS MER

7. 10. Synaptic organization of nociceptive relay nuclei in the cat and primate thalamus

   Författare :Ann-Charlott Ericson; Per Brodal; Linköpings universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : The fine structure of two thalamic nociceptive relay nuclei, the nucleus submedius (Sm) in the cat, and the posterior region in the owl monkey, was investigated using anatomical tract tracing techniques, immunohistochemical staining for neuroactive substances, and threedimensional reconstructions of synaptic circuitry. Ascending lamina I axons, labeled by anterograde transport of Phaseolus vulgaris leucoagglutinin, gave rise to two different types of termination in Sm: large, compact clusters of numerous boutons were predominant in the dense focus of the terminal field after a tracer injection at the site of nociceptive-specific neurons in lamina I, and boutons-of-passage type terminations were conspicuous in the periphery of a lamina I terminal field in Sm and predominant following a tracer injection at the site of thermoreceptive-specific neurons in lamina I. LÄS MER