Sökning: "Gamma-aminobutyric acid"
Visar resultat 16 - 18 av 18 avhandlingar innehållade orden Gamma-aminobutyric acid.
16. Leptin targets in the brain regulating body weight : receptors and down-stream mediators of leptin in neurons of the hypothalamus and brainstem
Sammanfattning : Obesity is a disease which has become a global epidemic that is beginning to replace undernutrition and infectious diseases as the most significant contributor to ill health in the world. In particular, obesity is associated with diabetes mellitus, hypertension and coronary heart disease. LÄS MER
17. Serotonin in emotional memory processes : neuropharmacological studies with emphasis on depression
Sammanfattning : Cognitive dysfunctions are common in neuropsychiatric disorders including Major Depressive Disorder, but are difficult to normalize by antidepressant therapies and contribute to reduced functional improvement. Cognitive impairments include alterations of emotional memory processes that are early targeted by antidepressant therapies, including Selective Serotonin Reuptake Inhibitors (SSRIs). LÄS MER
18. Rational and Combinatorial Engineering of Affinity Proteins Towards Therapeutical Applications
Sammanfattning : Protein engineering has had an immense impact on the development of biological drugs, including replacement therapies with engineered versions of insulin or factor VIII to treat diabetes or bleeding disorders, and monoclonal antibodies to treat cancer and various other malignancies. Now, with the next generation of treatment modalities coming up, including monoclonal reagents based on alternative scaffolds, gene and cell therapies, the importance of protein engineering to tailor-make these treatments is likely to increase further. LÄS MER