Sökning: "network cross-talk"

Visar resultat 1 - 5 av 17 avhandlingar innehållade orden network cross-talk.

1. 1. Functional association networks for disease gene prediction

   Författare :Dimitri Guala; Erik L L Sonnhammer; Hjalmar Brismar; Yves Moreau; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; network biology; biological networks; network prediction; functional association; functional coupling; network integration; functional association networks; genome-wide association networks; gene networks; protein networks; fret; functional enrichment analysis; network cross-talk; pathway annotation; gene prioritisation; network-based gene prioritization; benchmarking; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

   Sammanfattning : Mapping of the human genome has been instrumental in understanding diseasescaused by changes in single genes. However, disease mechanisms involvingmultiple genes have proven to be much more elusive. Their complexityemerges from interactions of intracellular molecules and makes them immuneto the traditional reductionist approach. LÄS MER

3. 2. Modelling and Analysis of Interconnects for Deep Submicron Systems-on-Chip

   Författare :Dinesh Pamunuwa; KTH; []
   Nyckelord :delay and noise modelling in VLSI circuits; cross-talk; interconnect modelling; timing analysis; transfer function; on-chip bus; bandwidth maximization; throughput maximization; repeater insertion; wire optimization;

   Sammanfattning : The last few decades have been a very exciting period in thedevelopment of micro-electronics and brought us to the brink ofimplementing entire systems on a single chip, on a hithertounimagined scale. However an unforeseen challenge has croppedup in the form of managing wires, which have become the mainbottleneck in performance, masking the blinding speed of activedevices. LÄS MER

4. 3. Mechanisms and genes controlling the signalling network for biotic and abiotic stress defences in Arabidopsis thaliana (L.) Heyhn : Functional cross-talk between photo-produced reactive oxygen species, photosynthesis and plant disease defence responses

   Författare :Christine Chi-Chen Chang; Stanislaw Karpinski; Christine Foyer; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; reactive oxygen species; Arabidopsis thaliana; signalling work; biotic stress; abiotic stress; Plant physiology; Växtfysiologi;

   Sammanfattning : Excess excitation energy, mechanical injury and defence against pathogens, each trigger rapid production of reactive oxygen species (ROS) in Arabidopsis thaliana leaves. ROS, such as hydrogen peroxide (H2O2), are required for the induction of systemic acquired acclimation and may lead to redox changes in photosynthetic electron transport (PET). LÄS MER

5. 4. Systematic Modular Approaches to Reveal DNA Damage Responses in Mammalian Cells

   Författare :J. Peter Svensson; Ingela Turesson; Jean Bourhis; Uppsala universitet; []
   Nyckelord :Molecular biology; gene expression profiling; DNA damage; network; cancer; ionizing radiation; cisplatin; Molekylärbiologi;

   Sammanfattning : Cancer therapy operates by inflicting damage in malignant cells. The most lethal target is the genomic DNA. As a single double strand DNA break has the potential to kill the cell, mechanisms have evolved to detect and block propagation of the damage. LÄS MER

7. 5. Calcium signaling and network activity : mathematical modeling and molecular mechanisms

   Författare :Erik Smedler; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The calcium (Ca2+) ion is a versatile second messenger present in all cells. It is involved in such diverse processes as cell division, differentiation, vesicle transport and muscle contraction. Its widespread applicability is partially explained by its wide temporal and spatial dynamics. LÄS MER