Sökning: "Enkefalin"

Hittade 2 avhandlingar innehållade ordet Enkefalin.

  1. 1. Metallocene based peptidomimetics and chiral catalysts

    Författare :Suzana Maricic; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Organisk kemi; asymmetric catalysis.; metallocene based amino alcohols; one-pot macrocyclisation; cyclic peptides; Organometallic substance P and Leu 5 -enkephalin; conformational analysis;

    Sammanfattning : Several optically active organometallic Phe-AAn-Phe peptidomimetics and macrocyclic Phe-(Phe)n peptides have been synthesized by either intra- or intermolecular peptide bond formation of the corresponding bis(amino acid) derivatives. The key bis(amino acid) derivatives were available from an improved multi-step synthetic route, utilising Horner-Wadswort-Emmons olefination of organometallic aldehydes with phosphonylglycine reagents, enantioselective hydrogenation of didehydro amino acids and classical solution and/or solid phase peptide synthesis methodology. LÄS MER

  3. 2. Physiological and pathophysiological regulation of ECL-cell activity

    Författare :Maria Lundgren; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacy; toxicology; Pharmacological sciences; pharmacognosy; Gastroenterologi; endothelin; gastrin; ischemia-reperfusion; Physiology; Fysiologi; Gastro-enterology; pancreastatin; histamine; microdialysis; ECL-cell; stomach; Farmakologi; farmakognosi; farmaci; toxikologi;

    Sammanfattning : The ECL cells are endocrine/paracrine cells located in the acid-producing part of the stomach. They produce and secrete histamine and chromogranin A-derived peptides in response to circulating gastrin. Mobilized histamine stimulates acid secretion from adjascent parietal cells. LÄS MER