Sökning: "Elongation factor"

Visar resultat 21 - 25 av 94 avhandlingar innehållade orden Elongation factor.

  1. 21. The Roles of Growth Factor Interactions and Mechanical Tension in Angiogenesis

    Författare :Ludvig Petersson; Pär Gerwins; Filip Farnebo; Uppsala universitet; []
    Nyckelord :angiogenesis; myofibroblast; wound healing; VEGF; FGF; PDGF; endocan; endothelial cell; vascularization; MEDICINE; MEDICIN; Medicin; Medicine;

    Sammanfattning : Angiogenesis, the formation of new blood vessels from preexisting ones through creation of new vessel branch points by sprouting or vessel splitting, is an important part of tissue growth in both physiological processes like wound healing and pathological conditions such as cancer. Growth factors like VEGF-A, FGF-2 and PDGF-BB are involved in both types of angiogenesis. LÄS MER

  3. 22. Regulation of gene and protein expression : two model systems

    Författare :Lars H Lund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HIV-1; EIAV; Tat; TAR; Cyclin T1; CDK9; P-TEFb; RNA polymerase II; gene regulation; transcriptional elongation; CEA; signal sequence.;

    Sammanfattning : Genetic information is expressed by DNA transcription and mRNA translation. With few exceptions, every cell of an organism, or the human body, contains the same genetic information. Yet the structure and function of different tissues are highly variable. LÄS MER

  4. 23. Dynamics in Protein Synthesis, Structural Studies of Translation Factors

    Författare :Martin Laurberg; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biophysics; Flexibility; Fusidic Acid; tRNA; Translation Factors; Ribosome; Molekylär biofysik;

    Sammanfattning : Protein biosynthesis is performed on ribosomes. The ribosome is a complex of ribosomal RNA and proteins forming two subunits. A messenger RNA strand is decoded on the small subunit by charged aminoacyl transfer RNA (aa-tRNA) molecules and each tRNA molecule delivers its amino acid to the growing polypeptide chain on the large subunit. LÄS MER

  5. 24. Metabolic Significance of Systemic DHA Deficiency

    Författare :Anna Maria Pauter; Anders Jacobsson; Bernadette Delplanque; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; fysiologi; Physiology;

    Sammanfattning : Fatty acid composition in the body displays a high level of heterogeneity and can rapidly respond to changes in diet regime or to starvation. Homeostasis of the level of certain fatty acids is an important factor for maintenance of structural integrity as well as for proper signaling within the organism. LÄS MER

  7. 25. Molecular Interplay of Antibiotics on the Bacterial Ribosome

    Författare :Narayan Prasad Parajuli; Suparna Sanyal; Michael Y. Pavlov; Chandra Sekhar Mandava; Axel Innis; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Ribosome; Translation; Antibiotics; Aminoglycoside; Thermorubin; Protein synthesis; Molekylär biovetenskap; Molecular Life Sciences;

    Sammanfattning : Inhibition of protein synthesis is one of the most common modes of action for medically useful antibiotics. This thesis presents the mechanistic studies of two chemically distinct classes of antibiotics that target bacterial ribosomes –aminoglycosides and thermorubin. LÄS MER