Sökning: "Chandra Sekhar Mandava"

Hittade 2 avhandlingar innehållade orden Chandra Sekhar Mandava.

1. 1. Ribosomal Stalk Protein L12 : Structure, Function and Application

   Författare :Chandra Sekhar Mandava; Suparna Sanyal; Knud Nierhaus; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Ribosome; protein synthesis; L12 dimer; initiation; elongation; G factors; and His-tag; Molecular biology; Molekylärbiologi; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

   Sammanfattning : Ribosomal stalk proteins are known to play important role in protein synthesis. The ‘stalk’, an extended structure on the large subunit of the ribosome is composed mainly of two to three dimers of L12 and one L10 protein, which forms the base of the stalk. In E. LÄS MER

3. 2. Molecular Interplay of Antibiotics on the Bacterial Ribosome

   Författare :Narayan Prasad Parajuli; Suparna Sanyal; Michael Y. Pavlov; Chandra Sekhar Mandava; Axel Innis; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Ribosome; Translation; Antibiotics; Aminoglycoside; Thermorubin; Protein synthesis; Molekylär biovetenskap; Molecular Life Sciences;

   Sammanfattning : Inhibition of protein synthesis is one of the most common modes of action for medically useful antibiotics. This thesis presents the mechanistic studies of two chemically distinct classes of antibiotics that target bacterial ribosomes –aminoglycosides and thermorubin. LÄS MER