Sökning: "Domain Evolution"

Visar resultat 26 - 30 av 192 avhandlingar innehållade orden Domain Evolution.

  1. 26. Modelling the evolution of treatment-induced resistance in Ph+ leukaemias

    Författare :Jonathan Lindström; Ran Friedman; Arne Traulsen; Linnéuniversitetet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chronic myeloid leukaemia; Stochastic modelling; Tyrosine kinase inhibitor; Drug resistance; Clonal evolution; Biomedical Sciences; Biomedicinsk vetenskap; Medicinsk kemi; Medical Chemistry;

    Sammanfattning : Targeted therapies are a mainstay of modern cancer treatments. Rather than harming rapidly dividing cells in general, targeted therapies work by directly interfering with oncogenic molecular pathways present in a tumour. Consequently, a targeted therapy typically has less severe side effects. LÄS MER

  3. 27. Variation in length of proteins by repeats and disorder regions

    Författare :Rauan Sagit; Arne Elofsson; Andrey Kajava; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein length; repeats; domain repeats; protein evolution; duplication; tandem duplication; intrinsic disorder; intrinsically disordered; variation in length; insertion; deletion; recombination; expansion; contraction; Biochemistry; biokemi;

    Sammanfattning : Protein-coding genes evolve together with their genome and acquire changes, some of which affect the length of their protein products. This explains why equivalent proteins from different species can exhibit length differences. LÄS MER

  4. 28. Spatial and Physical Splittings of Semilinear Parabolic Problems

    Författare :Erik Henningsson; Matematik LTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; splitting schemes; parabolic equations; semilinear; evolution equations; dissipative; convergence order; dimension splitting; domain decomposition; axonal growth;

    Sammanfattning : Splitting methods are widely used temporal approximation schemes for parabolic partial differential equations (PDEs). These schemes may be very efficient when a problem can be naturally decomposed into multiple parts. LÄS MER

  5. 29. The ABC of KRAB zinc finger proteins

    Författare :Camilla Looman; Lars Hellman; Lars-Gunnar Larsson; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biology; Krüppel zinc finger; KRAB; transcription; repression; evolution; Biologi; Biology; Biologi; immunologi; Immunology;

    Sammanfattning : All living organisms consist of cells and the identity of a cell is defined by the genes it expresses. To assure proper function, a cell receives continuous information on which genes to turn on and off. This information is, to a large extent, provided by transcription factors. LÄS MER

  7. 30. Calreticulins- Calcium-Binding Proteins with Functional Diversity and Evolutionary Duality

    Författare :Staffan Persson; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Plant biochemistry; plant; isoforms; evolution; diversity; differential regulation; chaperone; calnexin; calmegin; calcium; Arabidopsis; calreticulin; Växtbiokemi;

    Sammanfattning : Calreticulin is a multifunctional protein mainly localized in the endoplasmic reticulum in eukaryotic organisms, except yeasts. The protein comprises three distinct regions: the N-terminal N domain, the C-terminal C domain, and the central P domain, reflecting the functional diversity of calreticulin. LÄS MER