Sökning: "axonal growth"

Visar resultat 1 - 5 av 59 avhandlingar innehållade orden axonal growth.

  1. 1. Phospholipase A2 in nerve injury and axonal outgrowth

    Författare :Marie Hornfelt; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Neurology; cell death; apoptosis; leukotrienes; arachidonic acid; M-type receptor; secretory phospholipase A2; cytosolic phospholipase A2; sciatic nerve; dorsal root ganglia; growth cone; axonal outgrowth; nerve injury; peripheral nerve regeneration; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi; Animal physiology; Djurfysiologi;

    Sammanfattning : This thesis deals with processes coupled to injury in the peripheral nervous system (PNS), with a general aim to investigate the role of phospholipase A2 (PLA2) enzymes in axonal outgrowth. The axonal outgrowth of dorsal root ganglia (DRG) neurons in vitro was reduced by several different inhibitors of PLA2 activity and enhanced by an activator of this enzyme. LÄS MER

  2. 2. Vascular Endothelial Growth Factor (VEGF) and Peripheral Nerve Regeneration

    Författare :Mariann Sondell; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Schwann cell; SCG; rat; peripheral nerve regeneration; neuropilin-1; nerve repair; mouse; growth factor; flk-1; axonal outgrowth; DRG; VEGF; Animal physiology; Djurfysiologi;

    Sammanfattning : This thesis concerns vascular endothelial growth factor (VEGF) and its possible role as a neurotrophic factor. I have investigated the effect of VEGF on neurons in culture but also in vivo, following a crush lesion of the sciatic nerve, and following nerve repair. LÄS MER

  3. 3. Spatial and Physical Splittings of Semilinear Parabolic Problems

    Författare :Erik Henningsson; Matematik LTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; splitting schemes; parabolic equations; semilinear; evolution equations; dissipative; convergence order; dimension splitting; domain decomposition; axonal growth;

    Sammanfattning : Splitting methods are widely used temporal approximation schemes for parabolic partial differential equations (PDEs). These schemes may be very efficient when a problem can be naturally decomposed into multiple parts. LÄS MER

  4. 4. Neuroprotection and axonal regeneration after peripheral nerve injury

    Författare :Dag Welin; Lev N. Novikov; Lars B. Dahlin; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICAL AND HEALTH SCIENCES; Dorsal root ganglion; Motoneuron; Axonal reaction; Peripheral nerve injury; Nerve regeneration; N-acetylcysteine; Hand surgery; Handkirurgi; Anatomy; Anatomi; anatomi; Human Anatomy; handkirurgi; hand surgery;

    Sammanfattning : Following microsurgical reconstruction of injured peripheral nerves, severed axons are able to undergo spontaneous regeneration. However, the functional result is always unsatisfactory with poor sensory recovery and reduced motor function. LÄS MER

  5. 5. Controlled axonal outgrowth and cell reactions to nanostructures

    Författare :Fredrik Johansson; Funktionell zoologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Contact guidance; neuron; axon; fibroblast; macrophage; polymethylmethacrylate; porous silicon; nanowire; magnetic; immunoresponse; nanoimprint lithography; haptotaxis;

    Sammanfattning : The interface between living cells and artificial surfaces are highly relevant for biomedical applications such as implants and organized cell growth for tissue reconstruction as well as for basic science purposes. In the present thesis, we have studied axonal guidance on various nano-patterned surfaces such as polymethyl-meth-acrylate, porous silicon and on magnetically aligned Ni nanowires. LÄS MER