Sökning: "Domain Evolution"
Visar resultat 21 - 25 av 192 avhandlingar innehållade orden Domain Evolution.
21. Influenza Neuraminidase : Novel mechanisms of influenza NA that enable adaptation and promote diversification
Sammanfattning : Influenza A viruses (IAVs) are one of the most common human respiratory pathogens and are largely responsible for the seasonal influenza epidemics that cause mild to severe disease. The two IAV glycoproteins, hemagglutinin (HA or H) and neuraminidase (NA or N), serve as the major surface antigens and also are the main determinants of infectivity, pathogenicity and transmissibility. LÄS MER
22. Domain rearrangement and creation in protein evolution
Sammanfattning : Proteins are composed of domains, recurrent protein fragments with distinct structure, function and evolutionary history. Some domains exist only as single domain proteins, however, a majority of them are also combined with other domains. LÄS MER
23. Bridging the Gap between Development and Use : Support of Tailorability in Software Evolution
Sammanfattning : The intention of tailorable systems is to make it possible for end users to evolve an application to better fit altered requirements and tasks, and to make the system more endurable. This thesis discusses tailorable systems in the context of a rapidly changing business environment. LÄS MER
24. A Genetic Switch in Bacteriophages within the Peduovirinae Subfamily : Structure, Function and Evolution
Sammanfattning : The temperate bacteriophages in the Peduovirinae subfamily can either grow lytically or integrate into their bacterial host and form lysogeny. Which one of the two life cycles the phage will enter after infection is controlled by a transcriptional switch. LÄS MER
25. Evolution and Binding Mechanisms of Intrinsically Disordered Proteins
Sammanfattning : Intrinsically disordered proteins (IDPs) make up a considerable fraction of the proteome in eukaryotic organisms. These proteins often act as hubs in interaction networks, harbouring multiple interaction with other proteins, and thus evolution has to walk a tightrope to accommodate new interactions while maintaining the previously established interactions. LÄS MER